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These early insights into the mechanism(s) of resistance to miRNA-based therapies may be of importance as more miRNA-targeted therapies enter into the clinic.<\/jats:p>","DOI":"10.1073\/pnas.2103671118","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T15:41:22Z","timestamp":1628782882000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":22,"title":["miR-122\u2013based therapies select for three distinct resistance mechanisms based on alterations in RNA structure"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-2298","authenticated-orcid":false,"given":"Jasmin","family":"Chahal","sequence":"first","affiliation":[{"name":"Department of Microbiology &amp; Immunology, McGill University, Montr\u00e9al, QC H3G 1Y6, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1830-119X","authenticated-orcid":false,"given":"Luca F. 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