{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:43:59Z","timestamp":1790372639307,"version":"4.1.0"},"reference-count":24,"publisher":"National Academy of Sciences","issue":"39","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["22.005.023"],"award-info":[{"award-number":["22.005.023"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,9,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The human body detects foreign pathogens by T cells with specific receptors. These are not directly encoded in the genome but generated in a random process that combines small gene segments into functional subunits of the receptor. The\n                    <jats:inline-formula>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                        <mml:mi>\u03b2<\/mml:mi>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    -chain of the T cell receptor is normally composed of three such gene segments. Here we identify a group of T cells that lack the middle segment in their receptor sequence. We find that such sequences are mostly generated before birth, persist over a human lifetime, and, as a result, are excessively shared between individuals.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2104367118","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T15:25:13Z","timestamp":1632324313000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":12,"title":["TCR\u03b2 rearrangements without a D segment are common, abundant, and public"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-629X","authenticated-orcid":false,"given":"Peter C.","family":"de Greef","sequence":"first","affiliation":[{"name":"Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2130-691X","authenticated-orcid":false,"given":"Rob J.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00485"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","unstructured":"T. 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