{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:38:46Z","timestamp":1790807926208,"version":"4.1.0"},"reference-count":22,"publisher":"National Academy of Sciences","issue":"24","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-1845298"],"award-info":[{"award-number":["DGE-1845298"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003986","name":"Jacobs Foundation","doi-asserted-by":"publisher","award":["Early Career Research Fellowship"],"award-info":[{"award-number":["Early Career Research Fellowship"]}],"id":[{"id":"10.13039\/501100003986","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"HHS | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["1R34DA050297-01"],"award-info":[{"award-number":["1R34DA050297-01"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,6,15]]},"abstract":"<jats:p>\n                    Exposure to adversity can accelerate biological aging. However, existing biomarkers of early aging are either costly and difficult to collect, like epigenetic signatures, or cannot be detected until late childhood, like pubertal onset. We evaluated the hypothesis that early adversity is associated with earlier molar eruption, an easily assessed measure that has been used to track the length of childhood across primates. In a preregistered analysis (\n                    <jats:italic>n<\/jats:italic>\n                    = 117, ages 4 to 7 y), we demonstrate that lower family income and exposure to adverse childhood experiences (ACEs) are significantly associated with earlier eruption of the first permanent molars, as rated in T2-weighted magnetic resonance images (MRI). We replicate relationships between income and molar eruption in a population-representative dataset (National Health and Nutrition Examination Survey;\n                    <jats:italic>n<\/jats:italic>\n                    = 1,973). These findings suggest that the impact of stress on the pace of biological development is evident in early childhood, and detectable in the timing of molar eruption.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2105304118","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T15:37:44Z","timestamp":1623166664000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":33,"title":["Early life stress is associated with earlier emergence of permanent molars"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8281-9551","authenticated-orcid":false,"given":"Cassidy L.","family":"McDermott","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hilton","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne T.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula A.","family":"Tooley","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-9315","authenticated-orcid":false,"given":"Austin L.","family":"Boroshok","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-1845","authenticated-orcid":false,"given":"Muralidhar","family":"Mupparapu","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-0220","authenticated-orcid":false,"given":"JoAnna M.","family":"Scott","sequence":"additional","affiliation":[{"name":"School of Dentistry, University of Missouri\u2212Kansas City, Kansas City, MO 64108"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8698-7808","authenticated-orcid":false,"given":"Erin E.","family":"Bumann","sequence":"additional","affiliation":[{"name":"School of Dentistry, University of Missouri\u2212Kansas City, Kansas City, MO 64108"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-0028","authenticated-orcid":false,"given":"Allyson P.","family":"Mackey","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(98)00017-8"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0963721419837670"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000270"},{"key":"e_1_3_4_4_2","first-page":"88","volume-title":"The Handbook of Evolutionary Psychology: Foundations","author":"Del Giudice M.","year":"2016","unstructured":"M. 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Almonaitiene, I. Balciuniene, J. Tutkuviene, Factors influencing permanent teeth eruption. Stomatologija 12, 67\u201372 (2010).","journal-title":"Stomatologija"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016359509005969"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.08.019"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2015.10.005"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.4149\/endo_2011_02_99"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/jfo.jfds_37_19"},{"key":"e_1_3_4_20_2","first-page":"48612","article-title":"Analysis of complex survey samples","volume":"9","author":"Lumley T.","year":"2020","unstructured":"T. Lumley, Analysis of complex survey samples. J. Stat. Soft. 9, 48612 (2020).","journal-title":"J. Stat. Soft."},{"key":"e_1_3_4_21_2","unstructured":"C. McDermott Accelerated maturation. 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