{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:17:03Z","timestamp":1790432223048,"version":"4.1.0"},"reference-count":65,"publisher":"National Academy of Sciences","issue":"38","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA158073"],"award-info":[{"award-number":["R01CA158073"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA215067"],"award-info":[{"award-number":["R01CA215067"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA226852"],"award-info":[{"award-number":["R01CA226852"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["1P01CA174653"],"award-info":[{"award-number":["1P01CA174653"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA172272"],"award-info":[{"award-number":["R01CA172272"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R35 CA197606"],"award-info":[{"award-number":["R35 CA197606"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["TL1 TR000082"],"award-info":[{"award-number":["TL1 TR000082"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,9,21]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Upon DNA damage, ATM and ATR kinase phosphorylate CtIP at T855 and several other sites. This study identified a physiological role of DNA damage\u2013induced CtIP phosphorylation at T855 using mouse models. Specifically, we showed that while not affecting normal development and physiological DNA repair in developing lymphocytes, the T885A mutation of CtIP reduced the extent of DNA end resection, compromised the maintenance of the DNA damage\u2013induced G2\/M checkpoints, and delayed Myc-induced lymphomagenesis.<\/jats:p>","DOI":"10.1073\/pnas.2105440118","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T15:34:54Z","timestamp":1631633694000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":15,"title":["DNA damage\u2013induced phosphorylation of CtIP at a conserved ATM\/ATR site T855 promotes lymphomagenesis in mice"],"prefix":"10.1073","volume":"118","author":[{"given":"Xiaobin S.","family":"Wang","sequence":"first","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"},{"name":"Graduate Program of Pathobiology and Molecular Medicine, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demis","family":"Menolfi","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foon","family":"Wu-Baer","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Fangazio","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie N.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengping","family":"Shao","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-7697","authenticated-orcid":false,"given":"Yimeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5550-1468","authenticated-orcid":false,"given":"Brian J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verna M.","family":"Estes","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia M.","family":"Cupo","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Gautier","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"},{"name":"Department of Genetics and Development, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6819-7370","authenticated-orcid":false,"given":"Laura","family":"Pasqualucci","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"},{"name":"Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Dalla-Favera","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"},{"name":"Department of Genetics and Development, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032;"},{"name":"Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032;"},{"name":"Department of Immunology and Microbiology, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Baer","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"},{"name":"Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-1818","authenticated-orcid":false,"given":"Shan","family":"Zha","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;"},{"name":"Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032;"},{"name":"Department of Immunology and Microbiology, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032;"},{"name":"Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.016"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06020"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092449"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2010972117"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2007455117"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1808490115"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000110"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1940"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0915067107"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-110410-132435"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06337"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.09.009"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M909494199"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.9.3535-3542.2005"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181139"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131939"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07215"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.11.020"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.04.011"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003277"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.04.012"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00770-5"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2020.102874"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308757101"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81714-6"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.16.2055"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6658"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03064-z"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.02.019"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00182"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.4.1403"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297-483"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08633"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00671-2"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.02.024"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.11.001"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105482200"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.307900.117"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04866"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00308-13"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.043"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600206"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15129"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes9120589"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503331112"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.15.3127"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.04.002"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201401146"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1816539115"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.01.024"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.35"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.6.1317"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05953"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09585"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.193"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-7864(02)00151-9"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05268"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.67"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.09.001"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8605"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80619-6"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00002-6"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.8.1183"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000967"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07798-3"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2105440118","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2105440118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T08:20:01Z","timestamp":1649838001000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2105440118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,14]]},"references-count":65,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2021,9,21]]}},"alternative-id":["10.1073\/pnas.2105440118"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2105440118","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,14]]},"assertion":[{"value":"2021-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2105440118"}}