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We describe detailed T cell subset definitions and importantly identified a unique CD4\n                    <jats:sup>+<\/jats:sup>\n                    PD-1\n                    <jats:sup>+<\/jats:sup>\n                    CXCL13\n                    <jats:sup>+<\/jats:sup>\n                    CXCR5\n                    <jats:sup>\u2212<\/jats:sup>\n                    TFH-like subset that surrounds HRS cells, appears in close proximity to CXCR5\n                    <jats:sup>+<\/jats:sup>\n                    B cells, and is associated with poor clinical outcome. We also uncovered unique PD-1\/PD-L1 axis biology in LR-CHL, namely a negative correlation between PD-L1 genetic alterations on HRS cells and PD-1 protein expression in the tumor microenvironment. Importantly, our findings contribute to a deeper understanding of cellular cross-talk in LR-CHL, which may aid in the development of novel biomarkers and targeted treatment strategies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2105822118","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T18:25:16Z","timestamp":1633544716000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":57,"title":["Single-cell profiling reveals the importance of CXCL13\/CXCR5 axis biology in lymphocyte-rich classic Hodgkin lymphoma"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6782-8361","authenticated-orcid":false,"given":"Tomohiro","family":"Aoki","sequence":"first","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia (BC) Cancer, Vancouver, BC, Canada V5Z 1L3;"},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, 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