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Curli cross-seeds and colocalizes with \u03b1-syn both in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    neurons and human neuroblastoma cells. Curli-induced \u03b1-syn aggregations down-regulate mitochondrial genes, causing energy failure in neurons. Moreover, we found that curli may have general effects in promoting neuropathologies induced by different aggregation-prone proteins, such as A-\u03b2 in Alzheimer\u2019s disease, Huntingtin in Huntington\u2019s disease, and SOD1 in amyotrophic lateral sclerosis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2106504118","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T15:56:03Z","timestamp":1629388563000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":89,"title":["Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-8263","authenticated-orcid":false,"given":"Chenyin","family":"Wang","sequence":"first","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong, Hong Kong Special Administrative Region, 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