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Even therapies that succeed in cutaneous melanoma (CM) treatment have proven ineffectual for UM, highlighting both the distinct nature of these two melanomas and the need to understand the differences between them. Here, we show that autochthonous UM tumors are rapidly induced by activated YAP and can lack hyperactive ERK, highlighting YAP as a promising therapeutic target. We further show that\n                    <jats:italic>MITF<\/jats:italic>\n                    functions as a tumor suppressor in UM in contrast to its essential role in CM, establishing that MITF inhibition should not be entertained for UM treatment.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2107006119","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T14:17:00Z","timestamp":1651760220000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":25,"title":["MITF deficiency accelerates GNAQ-driven uveal melanoma"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2503-4015","authenticated-orcid":false,"given":"Grace B.","family":"Phelps","sequence":"first","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139"},{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2554-5237","authenticated-orcid":false,"given":"Hannah R.","family":"Hagen","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139"},{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6806-1518","authenticated-orcid":false,"given":"Adam","family":"Amsterdam","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139"},{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Lees","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139"},{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S89591"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309034"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1758834018757175"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.15586\/codon.cutaneousmelanoma.2017"},{"key":"e_1_3_4_5_2","first-page":"1071","article-title":"Cutaneous melanoma: From pathogenesis to therapy (Review)","volume":"52","author":"Leonardi G. C.","year":"2018","unstructured":"G. C. Leonardi , Cutaneous melanoma: From pathogenesis to therapy (Review). Int. J. 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