{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:48:48Z","timestamp":1790768928923,"version":"4.1.0"},"reference-count":67,"publisher":"National Academy of Sciences","issue":"44","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,11,2]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Mammalian sperm migration within the female reproductive tract requires navigational mechanisms, through which sperm respond to biophysical and biochemical cues. Previous studies revealed that biophysical cues for sperm in the female reproductive tract include fluid flow, wall architecture, and temperature gradients. Here, by exploring bovine sperm motion in microfluidic reservoirs and by developing theoretical and computational models, we demonstrate that sperm motility hyperactivation, which is part of a process that prepares sperm in the female tract for fertilization and involves an increase in the asymmetry of sperm flagellar beating, modulates sperm\u2013sidewall interactions and thus navigation via female tract wall architecture. Specifically, hyperactivation reduces the tendency of sperm to remain swimming along walls and promotes a response that resembles chemotaxis.<\/jats:p>","DOI":"10.1073\/pnas.2107500118","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T16:40:40Z","timestamp":1635525640000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":44,"title":["Mammalian sperm hyperactivation regulates navigation via physical boundaries and promotes pseudo-chemotaxis"],"prefix":"10.1073","volume":"118","author":[{"given":"Meisam","family":"Zaferani","sequence":"first","affiliation":[{"name":"College of Agriculture and Life Sciences, Departments of Food Science, Cornell University, Ithaca, NY 14853;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-8320","authenticated-orcid":false,"given":"Susan S.","family":"Suarez","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Department of Biomedical sciences, Cornell University, Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-9220","authenticated-orcid":false,"given":"Alireza","family":"Abbaspourrad","sequence":"additional","affiliation":[{"name":"College of Agriculture and Life Sciences, Departments of Food Science, Cornell University, Ithaca, NY 14853;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1893"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi047"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.02.007"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1500541112"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"e02403","DOI":"10.7554\/eLife.02403","article-title":"Rheotaxis facilitates upstream navigation of mammalian sperm cells","volume":"3","author":"Kantsler V.","year":"2014","unstructured":"V. Kantsler, J. Dunkel, M. Blayney, R. E. Goldstein, Rheotaxis facilitates upstream navigation of mammalian sperm cells. eLife 3, e02403 (2014).","journal-title":"eLife"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515159112"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800819115"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202934109"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9703"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210548110"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.89.032720"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav2111"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68693"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0203-149"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.03.027"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.083113"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2840"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh657"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028359"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0230193"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn029"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2244-2"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod59.1.39"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12570"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.026476"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.055038"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0797"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020911-153258"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-020-00390-9"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.11.007"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-09-0134"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.5.1606"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2136654100"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610286104"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod46.4.686"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.116.140632"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.140230"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.040733"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03341-4"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.039800"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd4914"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.114.108102"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01462-y"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/78\/5\/056601"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1140\/epjst\/e2016-60070-6"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.103.078101"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.114.258104"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep26669"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.120.068002"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.113.048101"},{"key":"e_1_3_4_51_2","volume-title":"Random Walks in Biology","author":"Berg H. C.","year":"1993","unstructured":"H. C. Berg, Random Walks in Biology (Princeton University Press, 1993)."},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8985"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703530104"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/948575"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1071\/RD18316"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1039\/b903043c"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1039\/b612140c"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060587"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/iox082"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.439356"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001600309"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120020105"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0550053"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod36.5.1191"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19980316)37:5<550::AID-ANIE550>3.0.CO;2-G"},{"key":"e_1_3_4_66_2","doi-asserted-by":"crossref","unstructured":"G. Farneb\u00e4ck \u201cTwo-frame motion estimation based on polynomial expansion\u201d in Scandinavian Conference on Image Analysis J. Bigun T. Gustavsson Eds. (Springer Berlin 2003) pp. 363\u2013370.","DOI":"10.1007\/3-540-45103-X_50"},{"key":"e_1_3_4_67_2","volume-title":"Microhydrodynamics: Principles and Selected Applications","author":"Kim S.","year":"2013","unstructured":"S. Kim, S. J. Karrila, Microhydrodynamics: Principles and Selected Applications (Courier Corporation, 2013)."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2107500118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T08:49:46Z","timestamp":1649839786000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2107500118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,29]]},"references-count":67,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2021,11,2]]}},"alternative-id":["10.1073\/pnas.2107500118"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2107500118","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,29]]},"assertion":[{"value":"2021-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2107500118"}}