{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:05:10Z","timestamp":1790309110862,"version":"4.1.0"},"reference-count":140,"publisher":"National Academy of Sciences","issue":"41","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42-ES004699"],"award-info":[{"award-number":["P42-ES004699"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R35-ES030443-01"],"award-info":[{"award-number":["R35-ES030443-01"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Credit Unions Kids at Heart","award":["Philanthropy Fund"],"award-info":[{"award-number":["Philanthropy Fund"]}]},{"DOI":"10.13039\/100007267","name":"Joe Andruzzi Foundation","doi-asserted-by":"publisher","award":["Philanthropy Fund"],"award-info":[{"award-number":["Philanthropy Fund"]}],"id":[{"id":"10.13039\/100007267","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CJ Buckley Pediatric Brain Tumor Fund","award":["Philanthropy Fund"],"award-info":[{"award-number":["Philanthropy Fund"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,10,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Cancer therapy, such as chemotherapy, induces tumor cell death (\u201cdebris\u201d), which can stimulate metastasis. Chemotherapy-generated debris upregulates soluble epoxide hydrolase (sEH) and the prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    receptor 4 (EP4), which triggers a macrophage-derived storm of proinflammatory and proangiogenic lipid autacoid and cytokine mediators. Although sEH inhibitors and EP4 antagonists are in clinical development for multiple inflammatory diseases, their combined role in cancer is unknown. Here, we show that the synergistic antitumor activity of sEH and EP4 inhibition suppresses hepato-pancreatic tumor growth, without overt toxicity, via macrophage phagocytosis of debris and counterregulation of a debris-stimulated cytokine storm. Thus, stimulating the resolution of inflammation via combined inhibition of sEH and EP4 may be an approach for preventing metastatic progression driven by cancer therapy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2107771118","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T16:37:04Z","timestamp":1633365424000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":27,"title":["Eicosanoid regulation of debris-stimulated metastasis"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3057-6997","authenticated-orcid":false,"given":"Jianjun","family":"Deng","sequence":"first","affiliation":[{"name":"Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an 710069, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria M.","family":"Haak","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-1728","authenticated-orcid":false,"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Entomology and Nematology, University of California, Davis, CA 95616;"},{"name":"UCD Comprehensive Cancer Center, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciele C.","family":"Kipper","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Barksdale","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hee","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Entomology and Nematology, University of California, Davis, CA 95616;"},{"name":"UCD Comprehensive Cancer Center, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Gartung","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane R.","family":"Bielenberg","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvakumar","family":"Subbian","sequence":"additional","affiliation":[{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ07103;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koc-Kan","family":"Ho","sequence":"additional","affiliation":[{"name":"Shenzhen Bay Laboratory, Gaoke Innovation Center, Shenzhen 518000, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ye","sequence":"additional","affiliation":[{"name":"Shenzhen Bay Laboratory, Gaoke Innovation Center, Shenzhen 518000, China;"},{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daidi","family":"Fan","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an 710069, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkui","family":"Sun","sequence":"additional","affiliation":[{"name":"Shenzhen Bay Laboratory, Gaoke Innovation Center, Shenzhen 518000, China;"},{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China;"},{"name":"Division of Discovery Research, Ionova Life Science Co., Ltd., Shenzhen 518118, China;"},{"name":"Division of Discovery Research, Ionova Biotherapeutics Co., Inc., Foshan 528000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1408-8317","authenticated-orcid":false,"given":"Bruce D.","family":"Hammock","sequence":"additional","affiliation":[{"name":"Department of Entomology and Nematology, University of California, Davis, CA 95616;"},{"name":"UCD Comprehensive Cancer Center, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipak","family":"Panigrahy","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"},{"name":"Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.05.008"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304369"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-24"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-015-0141-7"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0067"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1700455114"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan0026"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170681"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800019RR"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13767"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4564"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(79)90130-0"},{"key":"e_1_3_4_13_2","first-page":"891","article-title":"Promotion of pulmonary metastasis in mice by bleomycin-induced endothelial injury","volume":"46","author":"Orr F. W.","year":"1986","unstructured":"F. W. Orr, I. Y. Adamson, L. Young, Promotion of pulmonary metastasis in mice by bleomycin-induced endothelial injury. Cancer Res. 46, 891\u2013897 (1986).","journal-title":"Cancer Res."},{"key":"e_1_3_4_14_2","first-page":"884","article-title":"Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine","volume":"46","author":"Ormerod E. J.","year":"1986","unstructured":"E. J. Ormerod, C. A. Everett, I. R. Hart, Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine. Cancer Res. 46, 884\u2013890 (1986).","journal-title":"Cancer Res."},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2043"},{"key":"e_1_3_4_16_2","first-page":"4368","article-title":"Mutagenicity, tumorigenicity, and electrophilic reactivity of the stereoisomeric platinum(II) complexes of 1,2-diaminocyclohexane","volume":"41","author":"Leopold W. R.","year":"1981","unstructured":"W. R. Leopold, R. P. Batzinger, E. C. Miller, J. A. Miller, R. H. Earhart, Mutagenicity, tumorigenicity, and electrophilic reactivity of the stereoisomeric platinum(II) complexes of 1,2-diaminocyclohexane. Cancer Res. 41, 4368\u20134377 (1981).","journal-title":"Cancer Res."},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2013.10.005"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0256-3"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061403"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-1976"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.33168"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50848-z"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/1781391a0"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20673"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2385"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00560"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.12.059"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2016.90"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2018\/e792s"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00967-5"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00504"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1974.68"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1803999116"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800019RR"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2007412117"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0595-2"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2020.08.006"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030470"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-39406-0_9"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142093"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(94)00149-9"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI127282"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010201)91:3<578::AID-CNCR1037>3.0.CO;2-W"},{"key":"e_1_3_4_44_2","first-page":"177","article-title":"Correlation between apoptosis and histological grade of transitional cell carcinoma of urinary bladder","volume":"1","author":"Jalalinadoushan M.","year":"2004","unstructured":"M. Jalalinadoushan, H. Peivareh, A. Azizzadeh Delshad, Correlation between apoptosis and histological grade of transitional cell carcinoma of urinary bladder. Urol. J. 1, 177\u2013179 (2004).","journal-title":"Urol. J."},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.1999.0928"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.cej.0000198896.02185.68"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6890-13-24"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000798"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0711-780"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172044"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2792"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-39406-0_3"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.58"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.12.026"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13479"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97943"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2809"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2011.08.004"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521453113"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075107"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5431.1276"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2875"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1610242114"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100030200"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.06.006"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410432111"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25235488"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb1206"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13513"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-16-0818"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-0841-4"},{"key":"e_1_3_4_72_2","first-page":"27","article-title":"Inhibition of chronic pancreatitis and murine pancreatic intraepithelial neoplasia by a dual inhibitor of c-RAF and soluble epoxide hydrolase in LSL-KrasG12D\/Pdx-1-Cre mice","volume":"36","author":"Liao J.","year":"2016","unstructured":"J. Liao ., Inhibition of chronic pancreatitis and murine pancreatic intraepithelial neoplasia by a dual inhibitor of c-RAF and soluble epoxide hydrolase in LSL-KrasG12D\/Pdx-1-Cre mice. Anticancer Res. 36, 27\u201337 (2016).","journal-title":"Anticancer Res."},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.11.042"},{"key":"e_1_3_4_74_2","first-page":"5261","article-title":"Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice","volume":"33","author":"Zhang W.","year":"2013","unstructured":"W. Zhang ., Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice. Anticancer Res. 33, 5261\u20135271 (2013).","journal-title":"Anticancer Res."},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.114.097501"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.01.012"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.05.011"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.21918"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S150456"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00819"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-011-9303-2"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041019"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12475"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.90"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1271"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12153"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.1.559"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002448"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2984"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4348"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23826"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.07.075"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1338239"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000222"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31523"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.2000089"},{"key":"e_1_3_4_97_2","first-page":"2481","article-title":"Cytokine changes in response to radio-\/chemotherapeutic treatment in head and neck cancer","volume":"33","author":"Reers S.","year":"2013","unstructured":"S. Reers ., Cytokine changes in response to radio-\/chemotherapeutic treatment in head and neck cancer. Anticancer Res. 33, 2481\u20132489 (2013).","journal-title":"Anticancer Res."},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2000.s.015"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10138"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32479"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.034"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.06.025"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3859"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11351"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/89759"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107670"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.130.3380.918"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan3464"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215634"},{"key":"e_1_3_4_110_2","doi-asserted-by":"crossref","first-page":"e0155947","DOI":"10.1371\/journal.pone.0155947","article-title":"Surgical stress abrogates pre-existing protective T cell mediated anti-tumor immunity leading to postoperative cancer recurrence","volume":"11","author":"Ananth A. A.","year":"2016","unstructured":"A. A. Ananth ., Surgical stress abrogates pre-existing protective T cell mediated anti-tumor immunity leading to postoperative cancer recurrence. PLoS One 11, e0155947 (2016).","journal-title":"PLoS One"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2966"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201490147"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers2020305"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-017-1220-6"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.02.007"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.2-102.v1"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804000116"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.754433"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.18"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02586"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.01.040"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01174"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S60114"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00784-1"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00241"},{"key":"e_1_3_4_126_2","first-page":"131","article-title":"The biology of cell death in tumours","volume":"5","author":"Wyllie A. H.","year":"1985","unstructured":"A. H. Wyllie, The biology of cell death in tumours. Anticancer Res. 5, 131\u2013136 (1985).","journal-title":"Anticancer Res."},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690758"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.50.5.242"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00347-5"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950115)75:2<522::AID-CNCR2820750215>3.0.CO;2-W"},{"key":"e_1_3_4_131_2","first-page":"755","article-title":"Correlations between apoptotic and proliferative indices in malignant non-Hodgkin\u2019s lymphomas","volume":"142","author":"Leoncini L.","year":"1993","unstructured":"L. Leoncini ., Correlations between apoptotic and proliferative indices in malignant non-Hodgkin\u2019s lymphomas. Am. J. Pathol. 142, 755\u2013763 (1993).","journal-title":"Am. J. Pathol."},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00203394"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-01937-3"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15436"},{"key":"e_1_3_4_135_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-011-9315-y"},{"key":"e_1_3_4_136_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-018-9754-9"},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2009.141"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.015"},{"key":"e_1_3_4_139_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-0932"},{"key":"e_1_3_4_140_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97953"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2107771118","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2107771118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T08:41:36Z","timestamp":1649839296000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2107771118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,4]]},"references-count":140,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2021,10,12]]}},"alternative-id":["10.1073\/pnas.2107771118"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2107771118","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,4]]},"assertion":[{"value":"2021-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2107771118"}}