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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,9,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Thyroid hormones (T\n                    <jats:sub>4<\/jats:sub>\n                    and T\n                    <jats:sub>3<\/jats:sub>\n                    , TH) and fasting suppress the hypothalamic\u2013pituitary\u2013thyroid (HPT) axis. A mechanism for acute down-regulation of the HPT axis is described, involving phosphorylation of a thyroid hormone receptor (THR) B2 isoform at serine 101. S101 is a major THRB2 phosphorylation site not found on other THR isoforms but is present in other members of the nuclear hormone receptor superfamily. S101 is phosphorylated after T\n                    <jats:sub>3<\/jats:sub>\n                    binding and increases HPT axis sensitivity to T\n                    <jats:sub>3<\/jats:sub>\n                    inhibition. S101A is also phosphorylated by a fasting responsive pathway, yielding HPT axis suppression. A physiologically relevant THR phosphorylation function is described, permitting nutritional deprivation and TH to use a common mechanism for acute suppression of the HPT axis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2107943118","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T16:59:59Z","timestamp":1632157199000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":20,"title":["Thyroid hormone receptor phosphorylation regulates acute fasting-induced suppression of the hypothalamic\u2013pituitary\u2013thyroid axis"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3879-7751","authenticated-orcid":false,"given":"Svetlana","family":"Minakhina","sequence":"first","affiliation":[{"name":"Department of Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ 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