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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,9,21]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    During placentation, some trophoblast cells, termed spiral artery trophoblast giant cells (SpA-TGCs), invade the maternal decidua and replace arterial endothelial cells to increase blood supply to the placenta; how this directional trophoblast migration occurs remains unknown. We show here that planar cell polarity (PCP) signaling mediated by\n                    <jats:italic>VANGL2<\/jats:italic>\n                    in SpA-TGCs plays a key role in trophoblast movement and successful placentation. Mice with SpA-TGC progenitors deficient in\n                    <jats:italic>Vangl2<\/jats:italic>\n                    had pregnancy termination in mid-gestation due to increased random cell protrusion and compromised cell migration. We also found endocannabinoid signaling intersects with PCP signaling in directing trophoblast migration by direct association of CB1 and\n                    <jats:italic>VANGL2<\/jats:italic>\n                    . These results demonstrated that trophoblast invasion in placentation requires organized PCP.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2108201118","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T15:50:57Z","timestamp":1631634657000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":13,"title":["Cannabinoid and planar cell polarity signaling converges to direct placentation"],"prefix":"10.1073","volume":"118","author":[{"given":"Yeon Sun","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Reproductive Sciences, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45299;"},{"name":"College of Medicine, University of Cincinnati, Cincinnati, OH 45221;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingju","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences, Cincinnati Children\u2019s Hospital 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