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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,10,26]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Optimal follicular helper T (Tfh) cell differentiation and function are required for effective humoral immunity against infection, while improper Tfh cell responses are associated with autoimmunity and allergy. We demonstrate that G\u03b1\n                    <jats:sub>13<\/jats:sub>\n                    \u2014a G\u03b1 protein subunit known to be involved in mediating signals related to cytoskeletal integrity, chemotaxis, and migration\u2014acts as an essential positive regulator in Tfh cell development and function. The deletion of G\u03b1\n                    <jats:sub>13<\/jats:sub>\n                    in T cells results in dampened germinal center reactions in immunization and viral infection models. Mechanistically, G\u03b1\n                    <jats:sub>13<\/jats:sub>\n                    -RhoA-ROCK2 axis is responsible for the Tfh cell differentiation from na\u00efve precursors, and Rho agonists recuperate hampered Tfh cell function in G\u03b1\n                    <jats:sub>13<\/jats:sub>\n                    -deficient mice. Such mechanistic insight underscores the possibility of targeting G\u03b1\n                    <jats:sub>13<\/jats:sub>\n                    -mediated signaling to maneuver Tfh cell responses.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2108376118","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T21:26:04Z","timestamp":1634592364000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":13,"title":["Critical regulation of follicular helper T cell differentiation and function by G\u03b1\n                    <sub>13<\/sub>\n                    signaling"],"prefix":"10.1073","volume":"118","author":[{"given":"Da-Sol","family":"Kuen","sequence":"first","affiliation":[{"name":"Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea;"},{"name":"BK21 Plus program, College of Pharmacy, Seoul National 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