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The observed cellular phenotypic defects in\n                    <jats:italic>Pten<\/jats:italic>\n                    and\n                    <jats:italic>Fmr1<\/jats:italic>\n                    knockout (KO) could be rectified and restored by heterozygosity of\n                    <jats:italic>Pten<\/jats:italic>\n                    in\n                    <jats:italic>Fmr1<\/jats:italic>\n                    KO neurons. Additionally, increased expression of PTEN in background\n                    <jats:italic>Fmr1<\/jats:italic>\n                    KO animals suggests that FMRP negatively regulates PTEN, and we propose that introducing a combination of genetic mutations may normalize structural aspects of neuronal morphology by balancing each other\u2019s expression.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2109448119","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T14:14:36Z","timestamp":1649427276000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":12,"title":["<i>Pten<\/i>\n                    heterozygosity restores neuronal morphology in fragile X syndrome mice"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1064-8989","authenticated-orcid":false,"given":"Shivaprasad H.","family":"Sathyanarayana","sequence":"first","affiliation":[{"name":"Department of 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