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Furthermore, IRF8 signaling is required for i27-Breg development and loss of IL-27R\u03b1 or IL-27 function in B cells abrogates capacity of i27-Bregs to suppress diseases or induce B-1a differentiation into i27-Breg. i27-Breg requires activation by innate stimuli and is not antigen-specific, suggesting that i27-Breg would be effective immunotherapy for diverse autoimmune diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2109548118","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T16:26:47Z","timestamp":1636993607000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":75,"title":["IL-27\u2013producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases"],"prefix":"10.1073","volume":"118","author":[{"given":"Jin Kyeong","family":"Choi","sequence":"first","affiliation":[{"name":"Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), NIH, 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