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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (\n                    <jats:italic>Mtb<\/jats:italic>\n                    ) is the etiological agent of human tuberculosis (TB).\n                    <jats:italic>Mtb<\/jats:italic>\n                    can persist inside host macrophages by successfully adapting to intracellular conditions. Acquisition of balanced amounts of essential micronutrients is one such important process. Our studies have identified a metallophore produced on demand to restore\n                    <jats:italic>Mtb<\/jats:italic>\n                    zinc metabolic imbalance. These diacyl-diisonitrile lipopeptides, named kupyaphores, are specifically induced during infection and move in and out of cells to protect bacteria from host-mediated nutritional deprivation and intoxication. Furthermore, we identify an\n                    <jats:italic>Mtb<\/jats:italic>\n                    isonitrile\u00a0hydratase homolog\n                    <jats:italic>,<\/jats:italic>\n                    expressed in low-zinc conditions, which probably facilitates zinc release from kupyaphores. Identification of this zinc acquisition strategy could provide opportunities in future to understand systemic zinc dysbiosis and associated manifestations in TB patients.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2110293119","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T12:47:54Z","timestamp":1645534074000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Kupyaphores are zinc homeostatic metallophores required for colonization of\n                    <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1073","volume":"119","author":[{"given":"Kritee","family":"Mehdiratta","sequence":"first","affiliation":[{"name":"Council Of Scientific And Industrial Research\u2013Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi 110025, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biology, Indian Institute of Science Education and Research, Pashan, Pune 411008, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Sharma","sequence":"additional","affiliation":[{"name":"Immunometabolism Laboratory, National Institute of Immunology, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi S.","family":"Bhosale","sequence":"additional","affiliation":[{"name":"Immunometabolism Laboratory, National Institute of Immunology, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5920-2596","authenticated-orcid":false,"given":"Rahul","family":"Choudhury","sequence":"additional","affiliation":[{"name":"CSIR\u2013National Chemical Laboratory, Pune 411008, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0111-4101","authenticated-orcid":false,"given":"Dattatraya P.","family":"Masal","sequence":"additional","affiliation":[{"name":"CSIR\u2013National Chemical Laboratory, Pune 411008, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2043-8512","authenticated-orcid":false,"given":"Alzu","family":"Manocha","sequence":"additional","affiliation":[{"name":"Immunometabolism Laboratory, National Institute of Immunology, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4304-6450","authenticated-orcid":false,"given":"Bhushan Dilip","family":"Dhamale","sequence":"additional","affiliation":[{"name":"Immunometabolism Laboratory, National Institute of Immunology, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseem","family":"Khan","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Research Center, Translational Health Science and Technology Institute, Faridabad 121001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8253-7466","authenticated-orcid":false,"given":"Vivekanand","family":"Asokachandran","sequence":"additional","affiliation":[{"name":"Council Of Scientific And Industrial Research\u2013Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi 110025, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Sharma","sequence":"additional","affiliation":[{"name":"Council Of Scientific And Industrial Research\u2013Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi 110025, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Ikeh","sequence":"additional","affiliation":[{"name":"Barts &amp; 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