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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,10,5]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Methionine metabolism is dramatically affected by age and restricting methionine consumption extends the lifespan across different species. However, we have limited information on the activity of different branches of methionine metabolism during aging. Furthermore, how tissue-specific perturbation of methionine metabolism affects aging is not known. Here, by feeding\n                    <jats:sup>13<\/jats:sup>\n                    C5-methionine to\n                    <jats:italic>Drosophila<\/jats:italic>\n                    and tracing its fate in different branches of the methionine metabolism, we were able to identify impairments of methionine flux associated with aging. In addition, to deplete methionine in a tissue-specific manner, we created transgenic flies that express\n                    <jats:italic>Methioninase<\/jats:italic>\n                    . Strikingly,\n                    <jats:italic>Methioninase<\/jats:italic>\n                    expression even in a single tissue can dramatically extend the health- and lifespan.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2110387118","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T17:27:00Z","timestamp":1632936420000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":49,"title":["A genetic model of methionine restriction extends\n                    <i>Drosophila<\/i>\n                    health- and lifespan"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9852-8329","authenticated-orcid":false,"given":"Andrey A.","family":"Parkhitko","sequence":"first","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"Aging Institute of University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15260;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-6891","authenticated-orcid":false,"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Princeton University, Princeton, NJ 08544;"},{"name":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Filine","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Jouandin","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Leshchiner","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Binari","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"HHMI, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7450-2589","authenticated-orcid":false,"given":"John M.","family":"Asara","sequence":"additional","affiliation":[{"name":"Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115;"},{"name":"Department of Medicine, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Rabinowitz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Princeton University, Princeton, NJ 08544;"},{"name":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Perrimon","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"HHMI, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101188"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-8-14"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep00134"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101837"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt094"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2012.00865.x"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.282277.116"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.005"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58053"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2006.01.001"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30293"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.10.010"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12266"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4592"},{"key":"e_1_3_4_16_2","first-page":"269","article-title":"Low methionine ingestion by rats extends life span","volume":"123","author":"Orentreich N.","year":"1993","unstructured":"N. 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Tan ., Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients. 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