{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:57:18Z","timestamp":1781103438102,"version":"3.54.1"},"reference-count":65,"publisher":"National Academy of Sciences","issue":"5","license":[{"start":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T00:00:00Z","timestamp":1658620800000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1072113"],"award-info":[{"award-number":["APP1072113"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1136889"],"award-info":[{"award-number":["APP1136889"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1067940"],"award-info":[{"award-number":["APP1067940"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1162597"],"award-info":[{"award-number":["APP1162597"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DE160101142"],"award-info":[{"award-number":["DE160101142"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001061","name":"Rebecca L. Cooper Medical Research Foundation","doi-asserted-by":"publisher","award":["PG2019396"],"award-info":[{"award-number":["PG2019396"]}],"id":[{"id":"10.13039\/501100001061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Pain development and discomfort are universal features of spider envenomation, yet severe pain arising from bites by Old World spiders is poorly understood. Molecular analyses of the venom of the King Baboon spider revealed abundant expression of the inhibitory cystine knot peptide Pm1a. Synthetic Pm1a induces pain in mice while simultaneously enhancing proexcitatory sodium currents and decreasing inhibitory potassium currents. These concomitant effects promote hyperexcitability in pain-sensing neurons that can be reversed by pharmacological inhibition of voltage-gated sodium channels. The coordinated modulation of excitatory and inhibitory ion channels involved in pain propagation may represent an economical and effective defense strategy in pain-inducing defensive venoms.<\/jats:p>","DOI":"10.1073\/pnas.2110932119","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T16:26:05Z","timestamp":1643041565000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":19,"title":["Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2157-4532","authenticated-orcid":false,"given":"Rocio K.","family":"Finol-Urdaneta","sequence":"first","affiliation":[{"name":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia"},{"name":"Electrophysiology Facility for Cell Phenotyping and Drug Discovery, Wollongong, NSW 2522, Australia"},{"name":"Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-9839","authenticated-orcid":false,"given":"Rebekah","family":"Ziegman","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6841-4176","authenticated-orcid":false,"given":"Zoltan","family":"Dekan","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2546-7913","authenticated-orcid":false,"given":"Jeffrey R.","family":"McArthur","sequence":"additional","affiliation":[{"name":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia"},{"name":"Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-9514","authenticated-orcid":false,"given":"Stewart","family":"Heitmann","sequence":"additional","affiliation":[{"name":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Luna-Ramirez","sequence":"additional","affiliation":[{"name":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia"},{"name":"Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8961-7194","authenticated-orcid":false,"given":"Han-Shen","family":"Tae","sequence":"additional","affiliation":[{"name":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia"},{"name":"Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-1310","authenticated-orcid":false,"given":"Alexander","family":"Mueller","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-1744","authenticated-orcid":false,"given":"Hana","family":"Starobova","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-6897","authenticated-orcid":false,"given":"Yanni K.-Y.","family":"Chin","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"},{"name":"Centre for Advanced Imaging, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Wingerd","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eivind A. B.","family":"Undheim","sequence":"additional","affiliation":[{"name":"Centre for Advanced Imaging, University of Queensland, St. Lucia, QLD 4072, Australia"},{"name":"Centre for Biodiversity Dynamics, Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway"},{"name":"Centre for Ecology and Evolutionary Synthesis, Department of Bioscience, University of Oslo, 0316 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-2029","authenticated-orcid":false,"given":"Ben","family":"Cristofori-Armstrong","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"},{"name":"School of Biomedical Sciences, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6403-1282","authenticated-orcid":false,"given":"Adam P.","family":"Hill","sequence":"additional","affiliation":[{"name":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia"},{"name":"St Vincent's Clinical School, University of New South Wales Sydney, Darlinghurst, NSW 2010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-3983","authenticated-orcid":false,"given":"Volker","family":"Herzig","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"},{"name":"School of Science, Technology &amp; Engineering and GeneCology Research Centre, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2308-2200","authenticated-orcid":false,"given":"Glenn F.","family":"King","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"},{"name":"Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-9588","authenticated-orcid":false,"given":"Irina","family":"Vetter","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"},{"name":"School of Pharmacy, University of Queensland, Woolloongabba, QLD 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-0279","authenticated-orcid":false,"given":"Lachlan D.","family":"Rash","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"},{"name":"School of Biomedical Sciences, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-2288","authenticated-orcid":false,"given":"David J.","family":"Adams","sequence":"additional","affiliation":[{"name":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia"},{"name":"Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7454-6522","authenticated-orcid":false,"given":"Paul F.","family":"Alewood","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0359-x"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.02.008"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2020.12.003"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-6389-0_18"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2013.12.019"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004516117"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17976"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.1c00072"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp128"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2010.06.018"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11110626"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03873"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi100246u"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611364104"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42843"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.05.039"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2235"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/379257a0"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.2.629"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00777.2012"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00088.2009"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.11.011"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.12.007"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh514"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602813103"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000854"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2020.564980"},{"key":"e_1_3_4_28_2","volume-title":"Handbook for the Brain Dynamics Toolbox: Version 2020","author":"Heitmann S.","year":"2020","unstructured":"S. Heitmann, M. Breakspear, Handbook for the Brain Dynamics Toolbox: Version 2020 (bdtoolbox.org, 5th ed., 2020)."},{"key":"e_1_3_4_29_2","unstructured":"S. Heitmann J. R. McArthur A. P. Hill Control and Spm1a modified Nav1.8 and TTX-s sodium channel models. Zenodo . https:\/\/dx.doi.org\/10.5281\/zenodo.5009443. Deposited 2021."},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006293"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00100.2011"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10010015"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-32-10338.2003"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002333"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0468-18.2018"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-021-00444-w"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-23-10277.2002"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12990-015-0028-z"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5291-14.2015"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.12.002"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107941"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1911382117"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12731"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep23894"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.633679"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8585"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114107"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2433-18.2018"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.05.017"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00189-5"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.12.034"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103556"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00013"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62230-1"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415324111"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1679"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.116.5.637"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00735"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.054718"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.01.013"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.1.48"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi061457"},{"key":"e_1_3_4_63_2","volume-title":"Australian Code for the Care and Use of Animals for Scientific Purposes","author":"Australian National Health and Medical Research Council","year":"2013","unstructured":"Australian National Health and Medical Research Council, Australian Code for the Care and Use of Animals for Scientific Purposes (Australian Research Council, 8th Ed, 2013)."},{"key":"e_1_3_4_64_2","doi-asserted-by":"crossref","unstructured":"Y. K.-Y. Chin R. Ziegman P. F. Alewood The solution structure of omega-theraphotoxin-Pm1b isolated from King Baboon spider. RCSB Protein Data Bank. https:\/\/www.rcsb.org\/structure\/7JPM. Deposited 9 August 2020.","DOI":"10.2210\/pdb7jpm\/pdb"},{"key":"e_1_3_4_65_2","doi-asserted-by":"crossref","unstructured":"Y. Chin R. Ziegman P. Alewood The solution structure of omega-theraphotoxin-Pm1b isolated from King Baboon spider. Biological Magnetic Resonance Data Bank. https:\/\/bmrb.io\/data_library\/summary\/index.php?bmrbId=30785. Deposited 9 August 2020.","DOI":"10.2210\/pdb7jpm\/pdb"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2110932119","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2110932119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T14:16:14Z","timestamp":1658844974000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2110932119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,24]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1073\/pnas.2110932119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2110932119","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,24]]},"assertion":[{"value":"2021-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2110932119"}}