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A screen of interferon-inducible genes revealed Shiftless (SHFL) as a potent antiviral effector, inhibiting all\n                    <jats:italic>Flaviviridae<\/jats:italic>\n                    tested, including West Nile, Zika, dengue, yellow fever, and hepatitis C viruses. Mechanistic studies showed that SHFL inhibits viral replication at a point after translation of the incoming genome. In whole-body\n                    <jats:italic>Shfl<\/jats:italic>\n                    knockout (KO) mice, compared to wild-type mice, the\n                    <jats:italic>Shfl<\/jats:italic>\n                    KO mice were more susceptible to Zika virus. Notably,\n                    <jats:italic>Shfl<\/jats:italic>\n                    was uniquely required for controlling replication in the brain and spinal cord, demonstrating an unappreciated neuroprotective role for this effector in\u00a0vivo. SHFL is a key antiviral effector that specifically inhibits flavivirus genome replication, and\n                    <jats:italic>Shfl<\/jats:italic>\n                    protects mice from Zika virus\u2013induced neuropathogenesis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2111266118","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T13:35:41Z","timestamp":1638797741000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":34,"title":["Shiftless inhibits flavivirus replication in\u00a0vitro and is neuroprotective in a mouse model of Zika virus pathogenesis"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3391-4197","authenticated-orcid":false,"given":"Natasha W.","family":"Hanners","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina B.","family":"Mar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-207X","authenticated-orcid":false,"given":"Ian N.","family":"Boys","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Eitson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8806-8688","authenticated-orcid":false,"given":"Pamela C.","family":"De La Cruz-Rivera","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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