{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:51:48Z","timestamp":1793407908529,"version":"4.5.0"},"reference-count":60,"publisher":"National Academy of Sciences","issue":"48","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,11,30]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Our findings explain mechanistically the observed gene \u00d7 environment (G\u00d7E) interaction in mesotheliomas occurring in carriers of heterozygous germline\n                    <jats:italic>BAP1<\/jats:italic>\n                    mutations (\n                    <jats:italic>BAP1<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    ) exposed to asbestos. The increased amount of acetylated HMGB1 can be measured in the serum and may prove useful as a diagnostic\/prognostic biomarker of mesothelioma in\n                    <jats:italic>BAP1<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    individuals. Inhibition of HMGB1 secretion in\n                    <jats:italic>Bap1<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mutant mice exposed to asbestos significantly decreased the incidence of mesothelioma and prolonged the survival of those who developed mesothelioma. This strategy may be translated to carriers of germline\n                    <jats:italic>BAP1<\/jats:italic>\n                    mutations with the aim of decreasing their incidence of mesothelioma.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2111946118","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T16:41:27Z","timestamp":1637685687000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":32,"title":["BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene \u00d7 environment interaction with asbestos"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3746-7478","authenticated-orcid":false,"given":"Flavia","family":"Novelli","sequence":"first","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Bononi","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Theoretical Biological Physics, Rice University, Houston, TX 77005;"},{"name":"Hefei National Laboratory for Physical Sciences at the Microscale, Department of Physics, University of Science and Technology of China, Hefei, Anhui 230026, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Bai","sequence":"additional","affiliation":[{"name":"Center for Theoretical Biological Physics, Rice University, Houston, TX 77005;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7951-9267","authenticated-orcid":false,"given":"Simone","family":"Patergnani","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara 44121, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Kricek","sequence":"additional","affiliation":[{"name":"NBS-C BioScience &amp; Consulting GmbH, Vienna 1230, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellinor","family":"Haglund","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Hawaii, Honolulu, HI 96822;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1528-2701","authenticated-orcid":false,"given":"Joelle S.","family":"Suarez","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Tanji","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9842-2628","authenticated-orcid":false,"given":"Ronghui","family":"Xu","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Takanishi","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Minaai","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Pastorino","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Morris","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey I.","family":"Pass","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, New York University, New York, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haithem","family":"Barbour","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Montreal, Montreal, QC H1T 2M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1572-6571","authenticated-orcid":false,"given":"Giovanni","family":"Gaudino","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara 44121, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pinton","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara 44121, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-0388","authenticated-orcid":false,"given":"Jose N.","family":"Onuchic","sequence":"additional","affiliation":[{"name":"Center for Theoretical Biological Physics, Rice University, Houston, TX 77005;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haining","family":"Yang","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8928-8474","authenticated-orcid":false,"given":"Michele","family":"Carbone","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0265-y"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0213-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21572"},{"key":"e_1_3_4_4_2","first-page":"566","article-title":"The mortality of amphibole miners in South Africa, 1946-80","volume":"49","author":"Sluis-Cremer G. K.","year":"1992","unstructured":"G. K. Sluis-Cremer, F. D. Liddell, W. P. Logan, B. N. Bezuidenhout, The mortality of amphibole miners in South Africa, 1946-80. Br. J. Ind. Med. 49, 566\u2013575 (1992).","journal-title":"Br. J. Ind. Med."},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12601"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1594"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200911078"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2007622117"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg516"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316925111"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.128348"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087915"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12165"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006542107"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00858"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvf198"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3481"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep22850"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2020.02.01"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-1220"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6128"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309085110"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00396-10"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.06.020"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22798"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0178-0"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav4902"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.95"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3459"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.912"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101323"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11290"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)86524-9"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318297fa65"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00045-M"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.243"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105887108"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.07.029"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192222999"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15152"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2015.00148"},{"key":"e_1_3_4_42_2","first-page":"8","article-title":"HMGB1 increases radiosensitivity by interacting with HDAC1","volume":"35","author":"Xin H.","year":"2015","unstructured":"H. Xin , HMGB1 increases radiosensitivity by interacting with HDAC1. Chin. J. Radiol. Med. Prot. 35, 8\u201314 (2015).","journal-title":"Chin. J. Radiol. Med. Prot."},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.09.073"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094523"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa613"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.153"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.79.0352"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000471"},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","unstructured":"Y. Yoshikawa High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma. Proc. Natl. Acad. Sci. U.S.A. 113 13432\u201313437 (2016).","DOI":"10.1073\/pnas.1612074113"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70056-2"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0255"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.35"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1953"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13111"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02358.x"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034318"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.170207097"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp212541y"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.6b09347"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx407"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2111946118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T08:11:48Z","timestamp":1649837508000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2111946118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":60,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2021,11,30]]}},"alternative-id":["10.1073\/pnas.2111946118"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2111946118","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]},"assertion":[{"value":"2021-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2111946118"}}