{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:28:40Z","timestamp":1787005720622,"version":"build-2736575974"},"reference-count":48,"publisher":"National Academy of Sciences","issue":"39","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"name":"USDA-HATCH","award":["1015922"],"award-info":[{"award-number":["1015922"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM124701"],"award-info":[{"award-number":["GM124701"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,9,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    are maternally transmitted bacteria that infect most insects, making them the most common endosymbionts.\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    achieved this status by manipulating host reproduction. For example, many\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    cause cytoplasmic incompatibility (CI) that kills uninfected embryos. In females,\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    can rescue CI, promoting their spread to high frequencies in host populations. CI strength varies in nature from weak to strong. Importantly, strong CI enables\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    biocontrol strategies in mosquito systems, which protect millions of individuals from arboviruses. However, theory predicts that natural selection does not act to preserve genes that cause CI, suggesting mutations may disrupt it. We show that a single naturally observed mutation weakens CI by reducing deubiquitylation. These discoveries help elucidate the molecular basis of symbiont-induced reproductive manipulations.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2113271118","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T15:45:27Z","timestamp":1632239127000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["A single mutation weakens symbiont-induced reproductive manipulation through reductions in deubiquitylation efficiency"],"prefix":"10.1073","volume":"118","author":[{"given":"John F.","family":"Beckmann","sequence":"first","affiliation":[{"name":"Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0372-7008","authenticated-orcid":false,"given":"Kelley","family":"Van Vaerenberghe","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Montana, Missoula, MT 59801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2692-6007","authenticated-orcid":false,"given":"Daniel E.","family":"Akwa","sequence":"additional","affiliation":[{"name":"Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8269-7731","authenticated-orcid":false,"given":"Brandon S.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Montana, Missoula, MT 59801"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2020.1107"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-021-01686-y"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2003.2475"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2011(73)90141-9"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes11080852"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61989"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2018.12.004"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/oso\/9780198577867.003.0002","volume-title":"Influential Passengers: Inherited Microorganisms and Arthropod Reproduction","author":"Hoffmann A. 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