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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,3,8]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>reg<\/jats:sub>\n                    response following acute\n                    <jats:italic>Listeria<\/jats:italic>\n                    infection is heterogeneous and deploys two distinct modes of suppression coinciding with initial pathogen exposure and resolution of infection. This bimodal suppression of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells during priming and contraction is mediated by separate T\n                    <jats:sub>reg<\/jats:sub>\n                    lineages. These findings make a significant contribution to our understanding of the functional plasticity inherent within T\n                    <jats:sub>reg<\/jats:sub>\n                    <jats:sub>s<\/jats:sub>\n                    , which allows these cells to serve as a sensitive and dynamic cellular rheostat for the immune system to prevent autoimmune pathology in the face of inflammation attendant to acute infection, enable expansion of the pathogen-specific response needed to control the infection, and reestablish immune homeostasis after the threat has been contained.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2113329119","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T14:27:40Z","timestamp":1646317660000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":16,"title":["Developmentally distinct CD4\n                    <sup>+<\/sup>\n                    T\n                    <sub>reg<\/sub>\n                    lineages shape the CD8\n                    <sup>+<\/sup>\n                    T cell response to acute\n                    <i>Listeria<\/i>\n                    infection"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4602-8194","authenticated-orcid":false,"given":"Joseph S.","family":"Dolina","sequence":"first","affiliation":[{"name":"Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joey","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene L.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Hope","sequence":"additional","affiliation":[{"name":"Tumor Microenvironment and Cancer Immunology Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald T.","family":"Gracias","sequence":"additional","affiliation":[{"name":"Division of Immune Regulation, La Jolla Institute for Immunology, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4836-3375","authenticated-orcid":false,"given":"Takaji","family":"Matsutani","sequence":"additional","affiliation":[{"name":"Research and Development Department, Repertoire Genesis Incorporation, 567-0085 Ibaraki, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashu","family":"Chawla","sequence":"additional","affiliation":[{"name":"Bioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1381-0390","authenticated-orcid":false,"given":"Jason A.","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Bioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0689-1647","authenticated-orcid":false,"given":"Joel","family":"Linden","sequence":"additional","affiliation":[{"name":"Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Schoenberger","sequence":"additional","affiliation":[{"name":"Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp095"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3464"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142115"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). 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