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Therefore, APP and Notch may be the\n first identified substrates of a unique intramembranous aspartyl\n protease that has presenilin as its active-site component. In view of\n the evidence for a central role of cerebral build-up of A\u03b2 in the\n pathogenesis of Alzheimer's disease, this disorder appears to have\n arisen in the human population as a late-life consequence of the\n conservation of a critical developmental pathway.<\/jats:p>","DOI":"10.1073\/pnas.211352598","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:34:10Z","timestamp":1027679650000},"page":"11039-11041","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":167,"title":["Presenilin, Notch, and the genesis and treatment of Alzheimer's disease"],"prefix":"10.1073","volume":"98","author":[{"given":"Dennis J.","family":"Selkoe","sequence":"first","affiliation":[{"name":"Center for Neurologic Diseases, Harvard Medical School, Brigham and\r Women's Hospital, 77 Avenue Louis Pasteur, HIM 730, Boston, MA 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