{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:53:07Z","timestamp":1789433587897,"version":"build-2803163510"},"reference-count":37,"publisher":"National Academy of Sciences","issue":"24","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21 AI135369"],"award-info":[{"award-number":["R21 AI135369"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI056234"],"award-info":[{"award-number":["R01 AI056234"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,6,14]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    While ZBP1 is well documented to drive cell death in response to viruses, its role in the context of Toll-like receptor (TLR)\u2013mediated immune activation remains less defined. Here, we show that ZBP1 promotes inflammation in response to bacterial lipopolysaccharide (LPS) or double-stranded RNA (dsRNA). In a dose dependent manner, ZBP1 promotes the recruitment of RIPK1 to the TLR3\/4 adaptor TRIF, activating downstream inflammatory signaling. ZBP1 plays a crucial role in TRIF-dependent responses\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    , as\n                    <jats:italic>\n                      Zbp1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice exhibited resistance to LPS-induced hypothermia and attenuated inflammatory responses to dsRNA. Our findings suggest that ZBP1 plays a synergistic role in the immune response by driving inflammation downstream of TLRs in response to bacterial and viral components.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2113872119","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T15:02:27Z","timestamp":1654527747000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":83,"title":["ZBP1 promotes inflammatory responses downstream of TLR3\/TLR4 via timely delivery of RIPK1 to TRIF"],"prefix":"10.1073","volume":"119","author":[{"given":"Hayley I.","family":"Muendlein","sequence":"first","affiliation":[{"name":"Department of Immunology, Tufts University School of Medicine, Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson M.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Immunology, Tufts University School of Medicine, Boston, 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