{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:18:02Z","timestamp":1781108282062,"version":"3.54.1"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"41","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1 F31 NS115242-01"],"award-info":[{"award-number":["1 F31 NS115242-01"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000913","name":"James S. McDonnell Foundation","doi-asserted-by":"publisher","award":["220020516"],"award-info":[{"award-number":["220020516"]}],"id":[{"id":"10.13039\/100000913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,10,11]]},"abstract":"<jats:p>\n                    Advances in sequencing techniques have made comparative studies of gene expression a current focus for understanding evolutionary and developmental processes. However, insights into the spatial expression of genes have been limited by a lack of robust methodology. To overcome this obstacle, we developed methods and software tools for quantifying and comparing tissue-wide spatial patterns of gene expression within and between species. Here, we compare cortex-wide expression of\n                    <jats:italic>RZR\u03b2<\/jats:italic>\n                    and\n                    <jats:italic>Id2<\/jats:italic>\n                    mRNA across early postnatal development in mice and voles. We show that patterns of\n                    <jats:italic>RZR\u03b2<\/jats:italic>\n                    expression in neocortical layer 4 are highly conserved between species but develop rapidly in voles and much more gradually in mice, who show a marked expansion in the relative size of the putative primary visual area across the first postnatal week. Patterns of\n                    <jats:italic>Id2<\/jats:italic>\n                    expression, by contrast, emerge in a dynamic and layer-specific sequence that is consistent between the two species. We suggest that these differences in the development of neocortical patterning reflect the independent evolution of brains, bodies, and sensory systems in the 35 million years since their last common ancestor.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2113896119","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T13:46:07Z","timestamp":1665063967000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":3,"title":["Comparing the development of cortex-wide gene expression patterns between two species in a common reference frame"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-0588","authenticated-orcid":false,"given":"Sebastian S.","family":"James","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Sheffield, Sheffield S10 2TN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0098-7004","authenticated-orcid":false,"given":"Mackenzie","family":"Englund","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California Davis, Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4946-2997","authenticated-orcid":false,"given":"Riley","family":"Bottom","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California Riverside, Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1323-0772","authenticated-orcid":false,"given":"Roberto","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California Riverside, Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0471-9907","authenticated-orcid":false,"given":"Kathleen E.","family":"Conner","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California Riverside, Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly J.","family":"Huffman","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California Riverside, Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8125-5133","authenticated-orcid":false,"given":"Stuart P.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Sheffield, Sheffield S10 2TN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah A.","family":"Krubitzer","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California Davis, Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"e_1_3_5_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0602-1"},{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003266"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4260"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046658"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.07.009"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21709"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.52370"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064252"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr182"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000327320"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eep\/dvw019"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05453"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2281"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq213"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/27.3.909"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232806"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24856"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp082"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21314"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3454"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11416"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2018.12.003"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.112966"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04895"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1351"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/9.6.521"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.12.048"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2019.0672"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0156"},{"key":"e_1_3_5_30_2","first-page":"3483","article-title":"The 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Wilson M. Englund Stalefish. GitHub. https:\/\/github.com\/ABRG-Models\/Stalefish. Deposited 22 September 2022."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2113896119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T08:37:54Z","timestamp":1695285474000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2113896119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":36,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2022,10,11]]}},"alternative-id":["10.1073\/pnas.2113896119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2113896119","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]},"assertion":[{"value":"2021-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2113896119"}}