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Introduction of teprotumumab has resulted in a paradigm shift in the clinical management of TAO. Here, we demonstrate that teprotumumab and other IGF-I inhibitors attenuate MHC II and B7 expression in fibrocytes in TAO, both in\u00a0vitro and in patients treated with the drug in\u00a0vivo. This inhibition is associated with substantial reductions in two key inflammatory cytokines implicated in TAO. Thus, the current findings provide a plausible mechanism underlying the therapeutic responses to teprotumumab.<\/jats:p>","DOI":"10.1073\/pnas.2114244118","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T16:46:15Z","timestamp":1640277975000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":47,"title":["Therapeutic IGF-I receptor inhibition alters fibrocyte immune phenotype in thyroid-associated ophthalmopathy"],"prefix":"10.1073","volume":"118","author":[{"given":"Roshini","family":"Fernando","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-3051","authenticated-orcid":false,"given":"Oshadi","family":"Caldera","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6279-9685","authenticated-orcid":false,"given":"Terry J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510030"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0276"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1559633"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-68-1-154"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91475-2"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.4397"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.120"},{"key":"e_1_3_4_8_2","first-page":"160008","article-title":"Thyroid antibody-negative euthyroid Graves\u2019 ophthalmopathy","volume":"2016","author":"Tabasum A.","year":"2016","unstructured":"A. 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