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U.S.A."],"published-print":{"date-parts":[[2022,1,11]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Macrophages and dendritic cells represent an important target for HIV-1 replication in\u00a0vivo as they serve both as a vehicle for virus dissemination throughout the body and a viral reservoir. However, myeloid cells can support persistent replication of HIV-1 and, in contrast to infected T cells, demonstrate lower productivity. Using proteomics, we discovered that NRP-1 is a host restriction factor that inhibits HIV-1 from infecting macrophages and dendritic cells. NRP-1 is incorporated into the HIV-1 virion particle to inhibit its ability to attach to target cells in a viral envelope glycoprotein-independent manner. 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