{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:41:15Z","timestamp":1791423675635,"version":"4.3.3"},"reference-count":88,"publisher":"National Academy of Sciences","issue":"14","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001595","name":"Dystonia Medical Research Foundation","doi-asserted-by":"publisher","award":["Brain Networks in Dystonia"],"award-info":[{"award-number":["Brain Networks in Dystonia"]}],"id":[{"id":"10.13039\/100001595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["410169619"],"award-info":[{"award-number":["410169619"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["424778381"],"award-info":[{"award-number":["424778381"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002946","name":"Deutsches Zentrum f&#x00FC;r Luft- und Raumfahrt","doi-asserted-by":"publisher","award":["DynaSti"],"award-info":[{"award-number":["DynaSti"]}],"id":[{"id":"10.13039\/501100002946","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation for OCD Research","award":["Seed Grant"],"award-info":[{"award-number":["Seed Grant"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>We studied deep brain stimulation effects in two types of dystonia and conclude that different specific connections between the pallidum and thalamus are responsible for optimal treatment effects. Since alternative treatment options for dystonia beyond deep brain stimulation are scarce, our results will be crucial to maximize treatment outcome in this population of patients.<\/jats:p>","DOI":"10.1073\/pnas.2114985119","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T14:52:02Z","timestamp":1648738322000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":100,"title":["Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0695-6025","authenticated-orcid":false,"given":"Andreas","family":"Horn","sequence":"first","affiliation":[{"name":"Movement Disorder and Neuromodulation Unit, Department of Neurology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"},{"name":"Center for Brain Circuit Therapeutics, Department of Neurology, Brigham &amp; Women's Hospital, Harvard Medical School, Boston, MA 02115"},{"name":"Massachusetts General Hospital Neurosurgery, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin M.","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Neurology, Julius-Maximilians University W\u00fcrzburg, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Ewert","sequence":"additional","affiliation":[{"name":"Movement Disorder and Neuromodulation Unit, Department of Neurology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-3591","authenticated-orcid":false,"given":"Ningfei","family":"Li","sequence":"additional","affiliation":[{"name":"Movement Disorder and Neuromodulation Unit, Department of Neurology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam","family":"Al-Fatly","sequence":"additional","affiliation":[{"name":"Movement Disorder and Neuromodulation Unit, Department of Neurology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Neurology, Julius-Maximilians University W\u00fcrzburg, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Roothans","sequence":"additional","affiliation":[{"name":"Department of Neurology, Julius-Maximilians University W\u00fcrzburg, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Oxenford","sequence":"additional","affiliation":[{"name":"Movement Disorder and Neuromodulation Unit, Department of Neurology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Horn","sequence":"additional","affiliation":[{"name":"Movement Disorder and Neuromodulation Unit, Department of Neurology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9306-8332","authenticated-orcid":false,"given":"Steffen","family":"Paschen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Kiel, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Runge","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical School Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Wodarg","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Kiel, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Witt","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Oldenburg, 26129 Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-5494","authenticated-orcid":false,"given":"Robert C.","family":"Nickl","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Julius-Maximilians University W\u00fcrzburg, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Wittstock","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Rostock, 18051 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd-Helge","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Mahlknecht","sequence":"additional","affiliation":[{"name":"Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Poewe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Eisner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Innsbruck Medical University, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Kristin","family":"Helmers","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Kiel, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordula","family":"Matthies","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Julius-Maximilians University W\u00fcrzburg, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim K.","family":"Krauss","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical School Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-9196","authenticated-orcid":false,"given":"G\u00fcnther","family":"Deuschl","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Kiel, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Volkmann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Julius-Maximilians University W\u00fcrzburg, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-9060","authenticated-orcid":false,"given":"Andrea A.","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Movement Disorder and Neuromodulation Unit, Department of Neurology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063618"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70257-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13255"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0128-2"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20491"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz046"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.12.019"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16734-3"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24974"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.04.006"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.101.2.0181"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2011.00026"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-020-00220-5"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902270207"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2004.02.007"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16443"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.09.030"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25734"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70143-7"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.08.068"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.12.002"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.025"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(09)70884-5"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.09.061"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102271"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-019-0254-8"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","unstructured":"S. Oxenford Lead-OR: A multimodal platform for deep brain stimulation surgery. medRxiv[Preprint] (2020). https:\/\/www.medrxiv.org\/content\/10.1101\/2021.08.09.21261792v1 (Accessed 1 January 2022).","DOI":"10.1101\/2021.08.09.21261792"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.10.004"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.05.015"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117018"},{"key":"e_1_3_4_32_2","unstructured":"J. Vorwerk L. Magyari J. Ludewig R. Oostenveld C. H. Wolters The fieldtrip-simbio pipeline for finite element EEG forward computations in MATLAB: Validation and application. First International Conference on Basic and Clinical Multimodal Imaging BaCI Geneva Switzerland; August 9 2013."},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970728)384:2<312::AID-CNE10>3.0.CO;2-K"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/14075.001.0001"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2008.2012113"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176132"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2021.03.009"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13350"},{"key":"e_1_3_4_39_2","volume-title":"How to Build a Brain: A Neural Architecture for Biological Cognition. Reprint edition","author":"Eliasmith C.","year":"2015","unstructured":"C. Eliasmith, How to Build a Brain: A Neural Architecture for Biological Cognition. Reprint edition (Oxford University Press, 2015)."},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1119055"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt304"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.168"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2014.2363494"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6693"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2015.31"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy217"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.02.004"},{"key":"e_1_3_4_49_2","volume-title":"The Human Central Nervous System","author":"Nieuwenhuys R.","year":"2013","unstructured":"R. Nieuwenhuys, J. Voogd, C. van Huijzen, The Human Central Nervous System (Springer Science & Business Media, 2013)."},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235381"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90802-2"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.104.4.488"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25095"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1570-4"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440520"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.02.007"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn348"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.12.011"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.08.006"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27470"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz112"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90397-2"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02905-X"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70293-5"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101951"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64189-2.00017-2"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051169"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2753"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.01.003"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.3171\/2018.11.JNS182180"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0060-18.2018"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01922-6"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00090"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171958"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22196"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.404"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.8.1540"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000120541.97467.FE"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03054.x"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.10.011"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv109"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25567"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24204"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4674-12.2013"},{"key":"e_1_3_4_85_2","article-title":"Tractography of the ansa lenticularis in the human brain","author":"Li M.","year":"2022","unstructured":"M. Li , Tractography of the ansa lenticularis in the human brain. Clin. Anat.35, 269\u2013279 (2022).","journal-title":"Clin. Anat."},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz239"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/13\/3\/036023"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008023"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2114985119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T08:07:01Z","timestamp":1649837221000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2114985119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,31]]},"references-count":88,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2022,4,5]]}},"alternative-id":["10.1073\/pnas.2114985119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2114985119","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.07.28.21261289","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,31]]},"assertion":[{"value":"2021-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2114985119"}}