{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:39:41Z","timestamp":1793122781391,"version":"4.5.0"},"reference-count":54,"publisher":"National Academy of Sciences","issue":"8","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Since sepsis induces a sustained immunosuppression responsible for secondary infections acquisition and late mortality, restoring immune function would result in a better outcome. Given the role of arginine deficiency in T cell dysfunction, the evaluation of restoring arginine availability in sepsis has to be explored. Using an animal model of sepsis, we demonstrated that increasing arginine availability enhanced mitochondrial T cell function and decreased sepsis-induced immunosuppression.<\/jats:p>","DOI":"10.1073\/pnas.2115139119","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T16:45:39Z","timestamp":1645029939000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":51,"title":["Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7288-7769","authenticated-orcid":false,"given":"Florian","family":"Reizine","sequence":"first","affiliation":[{"name":"Laboratoire Suivi Immunologique des Th\u00e9rapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"},{"name":"Service des Maladies Infectieuses et R\u00e9animation M\u00e9dicale, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-7396","authenticated-orcid":false,"given":"Murielle","family":"Gr\u00e9goire","sequence":"additional","affiliation":[{"name":"Laboratoire Suivi Immunologique des Th\u00e9rapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3404-981X","authenticated-orcid":false,"given":"Mathieu","family":"Lesouhaitier","sequence":"additional","affiliation":[{"name":"Laboratoire Suivi Immunologique des Th\u00e9rapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"},{"name":"Service des Maladies Infectieuses et R\u00e9animation M\u00e9dicale, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2848-3097","authenticated-orcid":false,"given":"Valentin","family":"Coirier","sequence":"additional","affiliation":[{"name":"Laboratoire Suivi Immunologique des Th\u00e9rapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"},{"name":"Service des Maladies Infectieuses et R\u00e9animation M\u00e9dicale, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Laboratoire Suivi Immunologique des Th\u00e9rapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1510-6484","authenticated-orcid":false,"given":"C\u00e9line","family":"Delaloy","sequence":"additional","affiliation":[{"name":"Laboratoire Suivi Immunologique des Th\u00e9rapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-2898","authenticated-orcid":false,"given":"Elise","family":"Dessauge","sequence":"additional","affiliation":[{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Creusat","sequence":"additional","affiliation":[{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Uhel","sequence":"additional","affiliation":[{"name":"Laboratoire Suivi Immunologique des Th\u00e9rapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"},{"name":"Service des Maladies Infectieuses et R\u00e9animation M\u00e9dicale, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Gacouin","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et R\u00e9animation M\u00e9dicale, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Centre d\u2019Investigation Clinique de Rennes, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5785-2365","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Dessauge","sequence":"additional","affiliation":[{"name":"PEGASE, INRAE, Institut Agro, 35590 Saint Gilles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Le Naoures","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019anatomie pathologie, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-4078","authenticated-orcid":false,"given":"Caroline","family":"Moreau","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie, P\u00f4le Biologie, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2459-9567","authenticated-orcid":false,"given":"Claude","family":"Bendavid","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie, P\u00f4le Biologie, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoann","family":"Daniel","sequence":"additional","affiliation":[{"name":"UMR_A 1341, UMR_S 1241, INSERM, Institut de Nutrition, M\u00e9tabolismes et Cancer, Institut National de Recherche Agronomique, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4169-1744","authenticated-orcid":false,"given":"Kilian","family":"Petitjean","sequence":"additional","affiliation":[{"name":"UMR_A 1341, UMR_S 1241, INSERM, Institut de Nutrition, M\u00e9tabolismes et Cancer, Institut National de Recherche Agronomique, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-1053","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Bordeau","sequence":"additional","affiliation":[{"name":"BACTERIAL REGULATORY RNAS AND MEDICINE\u2013UMR_S 1230, INSERM, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Lamaison","sequence":"additional","affiliation":[{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Piau","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Cattoir","sequence":"additional","affiliation":[{"name":"BACTERIAL REGULATORY RNAS AND MEDICINE\u2013UMR_S 1230, INSERM, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"},{"name":"Service de Bact\u00e9riologie, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"Centre National de R\u00e9f\u00e9rence de la R\u00e9sistance aux Antibiotique (laboratoire associ\u00e9 \u201cEnt\u00e9rocoques\u201d), Centre Hospitalier Universitaire de Rennes, F-35043 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9741-0668","authenticated-orcid":false,"given":"Mikael","family":"Roussel","sequence":"additional","affiliation":[{"name":"Laboratoire Suivi Immunologique des Th\u00e9rapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2994-5465","authenticated-orcid":false,"given":"Bernard","family":"Fromenty","sequence":"additional","affiliation":[{"name":"UMR_A 1341, UMR_S 1241, INSERM, Institut de Nutrition, M\u00e9tabolismes et Cancer, Institut National de Recherche Agronomique, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Michelet","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et R\u00e9animation M\u00e9dicale, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Centre d\u2019Investigation Clinique de Rennes, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Le Tulzo","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et R\u00e9animation M\u00e9dicale, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Centre d\u2019Investigation Clinique de Rennes, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Zmijewski","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Thibault","sequence":"additional","affiliation":[{"name":"INSERM, Service d\u2019Endocrinologie, Diab\u00e9tologie et Nutrition, Institut National de Recherche Agronomoque, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Institut de Nutrition, M\u00e9tabolismes et Cancer, Institut National de Recherche Agronomique, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8519-4427","authenticated-orcid":false,"given":"Michel","family":"Cogn\u00e9","sequence":"additional","affiliation":[{"name":"Laboratoire Suivi Immunologique des Th\u00e9rapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Tarte","sequence":"additional","affiliation":[{"name":"Laboratoire Suivi Immunologique des Th\u00e9rapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7604-4849","authenticated-orcid":false,"given":"Jean-Marc","family":"Tadi\u00e9","sequence":"additional","affiliation":[{"name":"INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer\u2013UMR_S1236, \u00c9tablissement fran\u00e7aise du sang Bretagne, Universit\u00e9 de Rennes 2, F-35000 Rennes, France"},{"name":"Service des Maladies Infectieuses et R\u00e9animation M\u00e9dicale, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France"},{"name":"INSERM, Centre d\u2019Investigation Clinique de Rennes, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208623"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82224"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0503214"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-015-0058-8"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.165"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1829"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2506"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-017-0022-x"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2035"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.031"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2012.680634"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu7031426"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181d67494"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1668"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12567"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.7699"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.7698"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1711-5"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-2984-y"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-014-0026-8"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001212"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003033"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002074"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-4161-y"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200212000-00001"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2015-1"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-020-00920-5"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201606-1143OC"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00037.2016"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.226621"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.03.012"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31828611f8"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-031856"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3704"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc10112"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-1491"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05836-6"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.240382"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00093"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.6.1693S"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507841110"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02839"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903919106"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.062"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804119"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc11934"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001243"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001242"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001209"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.5HI0316-128RR"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182939831"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0210ST"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.7.2105078"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00151.2012"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2115139119","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2115139119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T09:01:38Z","timestamp":1649840498000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2115139119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,16]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,2,22]]}},"alternative-id":["10.1073\/pnas.2115139119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2115139119","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,16]]},"assertion":[{"value":"2021-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2115139119"}}