{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:30:32Z","timestamp":1781101832272,"version":"3.54.1"},"reference-count":25,"publisher":"National Academy of Sciences","issue":"13","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,3,29]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The treatment of hypoxemia that is refractory to the current standard of care is time-sensitive and requires skilled caregivers and use of specialized equipment (e.g., extracorporeal membrane oxygenation). Most patients experiencing refractory hypoxemia will suffer organ dysfunction, and death is common in this cohort. Here, we describe a new strategy to stabilize and support patients using a microfluidic device that administers oxygen gas directly to the bloodstream in real time and on demand using a process that we call sequential shear-induced bubble breakup. If successful, the described technology may help to avoid or decrease the incidence of ventilator-related lung injury from refractory hypoxemia.<\/jats:p>","DOI":"10.1073\/pnas.2115276119","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T15:15:37Z","timestamp":1647875737000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":15,"title":["A microfluidic device for real-time on-demand intravenous oxygen delivery"],"prefix":"10.1073","volume":"119","author":[{"given":"Ashwin Kumar","family":"Vutha","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"},{"name":"Department of Cardiology, Boston Children's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Patenaude","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0065-4672","authenticated-orcid":false,"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"},{"name":"Department of Cardiology, Boston Children's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Kheir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"},{"name":"Department of Cardiology, Boston Children's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0871-1064","authenticated-orcid":false,"given":"Brian D.","family":"Polizzotti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"},{"name":"Department of Cardiology, Boston Children's Hospital, Boston, MA 02115"},{"name":"Experimental Therapeutics Program, Dana Farber Cancer Institute\/Harvard Cancer Center, Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003679"},{"key":"e_1_3_4_2_2","first-page":"1271","article-title":"Interfacial nanoprecipitation toward stable and responsive microbubbles and their use as a resuscitative fluid","volume":"57","author":"Lock A. 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