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How EBV transforms these cells is incompletely understood, in particular in tumor cells such as Burkitt\u2019s lymphomas that do not express EBV\u2019s oncogenes. Here, we show that the EBV noncoding RNA EBER2 accelerates B cell division through overexpression of cyclin B1 and of Aurora kinases. Mechanistically, we found that EBER2 induces the expression of the UCHL1 deubiquitinase that itself modulates expression of the cell-cycle proteins. Interestingly, this effect is modulated by the lineage of the infected cell and by polymorphisms within the viral genome.<\/jats:p>","DOI":"10.1073\/pnas.2115508118","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T17:21:29Z","timestamp":1634923289000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":29,"title":["The Epstein\u2013Barr virus noncoding RNA EBER2 transactivates the UCHL1 deubiquitinase to accelerate cell growth"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1106-382X","authenticated-orcid":false,"given":"Zhe","family":"Li","sequence":"first","affiliation":[{"name":"Division of Pathogenesis of Virus Associated Tumors, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"},{"name":"INSERM, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Baccianti","sequence":"additional","affiliation":[{"name":"Division of Pathogenesis of Virus Associated Tumors, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"},{"name":"INSERM, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Delecluse","sequence":"additional","affiliation":[{"name":"Division of Pathogenesis of Virus Associated Tumors, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"},{"name":"INSERM, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Han","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoliy","family":"Shumilov","sequence":"additional","affiliation":[{"name":"Division of Pathogenesis of Virus Associated Tumors, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"},{"name":"INSERM, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianliang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Pathogenesis of Virus Associated Tumors, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"},{"name":"INSERM, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicong","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of T Cell Metabolism, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Research Group Mammalian Cell Cycle Control Mechanisms, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-3317","authenticated-orcid":false,"given":"Remy","family":"Poirey","sequence":"additional","affiliation":[{"name":"Division of Pathogenesis of Virus Associated Tumors, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"},{"name":"INSERM, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri-Jacques","family":"Delecluse","sequence":"additional","affiliation":[{"name":"Division of Pathogenesis of Virus Associated Tumors, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"},{"name":"INSERM, German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0249-7"},{"key":"e_1_3_4_2_2","first-page":"151","article-title":"EBV persistence--Introducing the virus","volume":"390","author":"Thorley-Lawson D. 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