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Here, we have developed a library of N-series lipid nanoparticles (LNPs) that could specifically regulate the protein composition of protein corona on the surface of LNPs, which allows specific delivery of mRNA to the lung. We further demonstrated that our lung-targeting LNP could effectively deliver mouse tuberous sclerosis complex 2 (\n                    <jats:italic>Tsc2<\/jats:italic>\n                    ) mRNA into TSC2-null cells and restore its function, resulting in enhanced control of tumor burden in a preclinical model of lymphangioleiomyomatosis, a destructive lung disease caused by loss-of-function mutations in the\n                    <jats:italic>Tsc2<\/jats:italic>\n                    gene.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2116271119","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T16:45:44Z","timestamp":1645029944000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":516,"title":["Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7373-2355","authenticated-orcid":false,"given":"Min","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Tufts University, Medford, MA 02155"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6223-8423","authenticated-orcid":false,"given":"Yan","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-5321","authenticated-orcid":false,"given":"Jinjin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Tufts University, Medford, MA 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