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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    N6-methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modifications play important roles in regulating RNA fate, in particular during viral infection. However, it remains unclear whether m\n                    <jats:sup>6<\/jats:sup>\n                    A modifications can also act in any antiviral capacity. During Kaposi\u2019s sarcoma\u2013associated herpesvirus infection, while most messenger RNA are degraded by the viral nuclease SOX, a subset of transcripts stringently escape degradation. Our study reveals that one such transcript, interleukin-6, acquires an m\n                    <jats:sup>6<\/jats:sup>\n                    A modification during the course of infection, which allows it to recruit the m\n                    <jats:sup>6<\/jats:sup>\n                    A reader YTHDC2. We show that this m\n                    <jats:sup>6<\/jats:sup>\n                    A modification along with the concomitant recruitment of YTHDC2 is essential to provide protection from SOX-induced decay. This suggests that m\n                    <jats:sup>6<\/jats:sup>\n                    A modifications can contribute to the host efforts to regain control of the gene expression environment.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2116662119","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T16:15:22Z","timestamp":1645114522000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":41,"title":["The m\n                    <sup>6<\/sup>\n                    A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay"],"prefix":"10.1073","volume":"119","author":[{"given":"Daniel","family":"Macveigh-Fierro","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Massachusetts, Amherst, MA 01003"},{"name":"Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Cicerchia","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Massachusetts, Amherst, MA 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Cadorette","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Massachusetts, Amherst, MA 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-3667","authenticated-orcid":false,"given":"Vasudha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Massachusetts, Amherst, MA 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0056-3589","authenticated-orcid":false,"given":"Mandy","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Massachusetts, Amherst, MA 01003"},{"name":"Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"4756","article-title":"KSHV SOX mediated host shutoff: The molecular mechanism underlying mRNA transcript processing","volume":"45","author":"Lee H.","year":"2017","unstructured":"H. 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