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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,1,18]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Persistent viral infection remains a major source of global morbidity and mortality. Studies using a persistent clone of lymphocytic choriomeningitis virus (LCMV) revealed that in addition to optimal functions and interactions of T and B cells, production of cytokines is essential in promoting long-term control of infection. Here we report that B cells are an indispensable source of IL-27 during persistent LCMV infection. B cell\u2013derived IL-27 promotes viral control via supporting accumulations of virus-specific CD8 and CD4 T cells. During later stages of infection, B cell\u2013derived IL-27 promotes production of IFN-\u03b3 and IL-21 by virus-specific CD4 T and Tfh cells, respectively. Our study unveils the critical role of a B cell\u2013secreted cytokine in controlling a persistent infection.<\/jats:p>","DOI":"10.1073\/pnas.2116741119","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T17:16:11Z","timestamp":1642007771000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":34,"title":["B cell\u2013derived IL-27 promotes control of persistent LCMV infection"],"prefix":"10.1073","volume":"119","author":[{"given":"Isaraphorn","family":"Pratumchai","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037"},{"name":"Department of Immunology, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-856X","authenticated-orcid":false,"given":"Jaroslav","family":"Zak","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Booki","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0804-0501","authenticated-orcid":false,"given":"Michael B. 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Zak I. Pratumchai J. R. Teijaro IL-27 production by splenic immune cells throughout persistent LCMV infection. Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE186898. 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