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Additionally, we show activation of dopaminergic circuits by acute cocaine administration in iMSN-D2RKO mice reprograms the circadian liver metabolome in response to cocaine. D2R signaling in MSNs is key for striatal output and essential for regulating the first response to the cellular and rewarding effects of cocaine. Our results suggest changes in dopamine signaling in specific striatal neurons evoke major changes in liver physiology. Dysregulation of liver metabolism could contribute to an altered allostatic state and therefore be involved in continued use of drugs.<\/jats:p>","DOI":"10.1073\/pnas.2117113119","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T14:14:57Z","timestamp":1646921697000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":10,"title":["Dopamine D2 receptor signaling in the brain modulates circadian liver metabolomic profiles"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4619-6144","authenticated-orcid":false,"given":"Marlene","family":"Cervantes","sequence":"first","affiliation":[{"name":"INSERM U1233, Center for Epigenetics and Metabolism, University of California, Irvine, CA 92697"},{"name":"Department of Biological Chemistry, University of California, Irvine, CA 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