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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,2,8]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Originally isolated from the red alga\n                    <jats:italic>Chondria armata<\/jats:italic>\n                    , domoic acid (DA) is best known as a potent marine neurotoxin produced by oceanic harmful algal blooms of planktonic diatoms. Sequencing efforts to date of kainoid-producing red algae have focused exclusively on a closely related molecule, kainic acid, leaving a gap in the understanding of DA biosynthesis in red algae and its evolutionary linkage to diatoms. Here, we present the phylogenetic and biochemical investigation of DA biosynthesis in\n                    <jats:italic>C. armata<\/jats:italic>\n                    . This work demonstrates the high synteny of DA biosynthetic genes between relatively distant taxonomic groups of algae and suggests a complex evolutionary history for DA biosynthesis involving gene transfer and neofunctionalization.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2117407119","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T15:46:33Z","timestamp":1643816793000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":53,"title":["Domoic acid biosynthesis in the red alga\n                    <i>Chondria armata<\/i>\n                    suggests a complex evolutionary history for toxin production"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3231-0639","authenticated-orcid":false,"given":"Taylor S.","family":"Steele","sequence":"first","affiliation":[{"name":"Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093"},{"name":"Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Brunson","sequence":"additional","affiliation":[{"name":"Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093"},{"name":"Microbial and Environmental Genomics Group, J. 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Craig Venter Institute, La Jolla, CA 92037"},{"name":"Integrative Oceanography Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-0409","authenticated-orcid":false,"given":"Mari","family":"Yotsu-Yamashita","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural Science, Tohoku University, Sendai 980-8572, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4651-0594","authenticated-orcid":false,"given":"Jonathan R.","family":"Chekan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC 27412"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-1253","authenticated-orcid":false,"given":"Bradley S.","family":"Moore","sequence":"additional","affiliation":[{"name":"Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093"},{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hal.2011.10.025"},{"key":"e_1_3_4_2_2","first-page":"7","article-title":"Amnesic shellfish poisoning: A new clinical syndrome due to domoic acid","volume":"16","author":"Perl T. 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