{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:59:03Z","timestamp":1788994743701,"version":"build-2803163510"},"reference-count":33,"publisher":"National Academy of Sciences","issue":"44","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2020YFA0509200"],"award-info":[{"award-number":["2020YFA0509200"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971487"],"award-info":[{"award-number":["81971487"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673073"],"award-info":[{"award-number":["81673073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974471"],"award-info":[{"award-number":["81974471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2020CR6022"],"award-info":[{"award-number":["SHDC2020CR6022"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20ZR1430200"],"award-info":[{"award-number":["20ZR1430200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20142202300"],"award-info":[{"award-number":["20142202300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases","award":["none"],"award-info":[{"award-number":["none"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>\n                    V\u03b39V\u03b42 T cells play an important role in the development and progression of psoriasis vulgaris (PV), but how they promote skin inflammation and the molecular mechanisms underlying V\u03b39V\u03b42 T cell dysfunction are poorly understood. Here, we show that circulating V\u03b39V\u03b42 T cells are decreased and exhibit enhanced proliferation and increased production of IFN-\u03b3 and TNF-\u03b1 in PV patients. Monocytes from PV patients express higher levels of the phosphoantigen sensor butyrophilin 3A1 (BTN3A1) than monocytes from healthy controls. Blockade of BTN3A1 suppresses V\u03b39V\u03b42 T cell activation and abolishes the difference in V\u03b39V\u03b42 T cell activation between PV patients and healthy controls. The CD14\n                    <jats:sup>+<\/jats:sup>\n                    cells in PV skin lesions highly express BTN3A1 and juxtapose to V\u03b42 T cells. In addition, IFN-\u03b3 induces the up-regulation of BTN3A1 on monocytes. Collectively, our results demonstrate a crucial role of BTN3A1 on monocytes in regulating V\u03b39V\u03b42 T cell activation and highlight BTN3A1 as a potential therapeutic target for psoriasis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2117523119","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T13:54:37Z","timestamp":1666792477000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":26,"title":["Up-regulation of BTN3A1 on CD14\n                    <sup>+<\/sup>\n                    cells promotes V\u03b39V\u03b42 T cell activation in psoriasis"],"prefix":"10.1073","volume":"119","author":[{"given":"Jiaqing","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College of Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-415X","authenticated-orcid":false,"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Immunology, Department of Immunology and Microbiology, and Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"},{"name":"Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College of Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College of Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College of Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College of Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College of Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College of Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Su","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Immunology, Department of Immunology and Microbiology, and Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"},{"name":"Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"},{"name":"Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Immunology, Department of Immunology and Microbiology, and Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"},{"name":"Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"},{"name":"Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-7022","authenticated-orcid":false,"given":"Zhenghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College of Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shen","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Immunology, Department of Immunology and Microbiology, and Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"},{"name":"Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"},{"name":"Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.594735"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.004"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.001"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101817"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61862"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700826"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4986"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508990112"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100804"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90178-7"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00483-6"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-010-0839-8"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-430470"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2665"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.03.003"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201601370RR"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.02.016"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1278099"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425227"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600913"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030235"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00749.x"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186604"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081438"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010179"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02530-7"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1495-x"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12923"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14365-1"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01097-8"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","unstructured":"J. Zhou Up-regulation of BTN3A1 on CD14 + cells promotes V\u03b39V\u03b42 T cell activation in psoriasis. NCBI Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE173387. Deposited 27 April 2021.","DOI":"10.1073\/pnas.2117523119"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2117523119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T08:31:38Z","timestamp":1695285098000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2117523119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":33,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1073\/pnas.2117523119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2117523119","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"assertion":[{"value":"2021-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2117523119"}}