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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Rational control of arthropod pests is important for animal and human health as well as biodiversity preservation. As an alternative to synthetic chemical pesticides, natural repellents represent an ecological method of pest control. Through an exceptional gene library screening in\n                    <jats:italic>Mesobuthus martensii<\/jats:italic>\n                    scorpions, we here uncover a transient receptor potential ion channel as the chemosensory sensor for plant-derived repellents. Its ortholog ion channel in\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    also acts as a molecular receptor of natural repellents and mediates avoidance behavior. This work thus identifies a molecular basis for arthropod chemosensing and should help update the ecological strategies for pest control while preserving biodiversity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2118152119","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T16:11:20Z","timestamp":1650643880000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":14,"title":["Identification of an arthropod molecular target for plant-derived natural repellents"],"prefix":"10.1073","volume":"119","author":[{"given":"Quan","family":"Tian","sequence":"first","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China"},{"name":"Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China"},{"name":"Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430072, China"},{"name":"Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, Hubei 430072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China"},{"name":"Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China"},{"name":"Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430072, China"},{"name":"Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, Hubei 430072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China"},{"name":"Hubei Key Laboratory of Cell 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China"},{"name":"Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-841X","authenticated-orcid":false,"given":"Michael X.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-4771","authenticated-orcid":false,"given":"Dongdong","family":"Li","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institute of Biology 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Tian Identification of an arthropod molecular target for plant-derived natural repellents. 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