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This study, therefore, provides a unifying mechanistic link between Chr1 and Chr10 risk and suggests that mast cell infiltration of the choroid and degranulation are early events in AMD pathogenesis.<\/jats:p>","DOI":"10.1073\/pnas.2118510119","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T14:43:56Z","timestamp":1652453036000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":32,"title":["Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9111-3064","authenticated-orcid":false,"given":"Selina","family":"Mcharg","sequence":"first","affiliation":[{"name":"Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Booth","sequence":"additional","affiliation":[{"name":"Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahat","family":"Perveen","sequence":"additional","affiliation":[{"name":"Manchester Centre for Genomic Medicine, Saint Mary\u2019s Hospital, Manchester University NHS (National Health Service) Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Riba Garcia","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6047-5193","authenticated-orcid":false,"given":"Nicole","family":"Brace","sequence":"additional","affiliation":[{"name":"Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadhim","family":"Bayatti","sequence":"additional","affiliation":[{"name":"Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis I.","family":"Sergouniotis","sequence":"additional","affiliation":[{"name":"Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, United Kingdom"},{"name":"Manchester Centre for Genomic Medicine, Saint Mary\u2019s Hospital, Manchester University NHS (National Health Service) Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom"},{"name":"Manchester Royal Eye Hospital, Manchester University NHS (National Health Service) Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool L69 3GJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1415-3134","authenticated-orcid":false,"given":"Anthony J.","family":"Day","sequence":"additional","affiliation":[{"name":"Division of Cell-Matrix Biology &amp; Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine &amp; Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, United Kingdom"},{"name":"Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine &amp; Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, United Kingdom"},{"name":"Wellcome Centre for Cell-Matrix Research, School of Biological Sciences, Faculty of Biology, Medicine &amp; Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme C. 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