{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:18:56Z","timestamp":1790680736664,"version":"4.1.0"},"reference-count":65,"publisher":"National Academy of Sciences","issue":"8","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 HL140496"],"award-info":[{"award-number":["RO1 HL140496"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The regulation of functional immune cell plasticity is poorly understood. Host environmental cues are critical, but the possible influence of pathogen-derived virulence factors has not been described. We have used reverse-engineered influenza A viruses that differ in PB1-F2 activity to analyze influenza in mice in the presence or absence of host interferon (IFN)-\u03b3. In the absence of functional PB1-F2 and IFN-\u03b3, lung ILC2s initiated robust IL-5 responses following viral challenge, which led to improved tissue integrity and survival. Conversely, functional PB1-F2 suppressed IL-5\n                    <jats:sup>+<\/jats:sup>\n                    ILC2 responses and induced a dominant IL-13\n                    <jats:sup>+<\/jats:sup>\n                    CD8 T cell response regardless of host IFN-\u03b3. These findings demonstrate the critical interplay between the viral virulence factors and host cytokines in regulating protective pulmonary immunity during influenza virus infection.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2118535119","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T16:41:30Z","timestamp":1644943290000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":16,"title":["Viral PB1-F2 and host IFN-\u03b3 guide ILC2 and T cell activity during influenza virus infection"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-4526","authenticated-orcid":false,"given":"Tarani Kanta","family":"Barman","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor C.","family":"Huber","sequence":"additional","affiliation":[{"name":"Division of Basic Biomedical Sciences, University of South Dakota, 414 E Clark St, Vermillion, South Dakota 57069"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse L.","family":"Bonin","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Califano","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Salmon","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N. J.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-9907","authenticated-orcid":false,"given":"Dennis W.","family":"Metzger","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2013.05.001"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.017"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2010.0076"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12085"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2014.06.004"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2131"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2045"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.41"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-110119-091711"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08636"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08900"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003988107"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08901"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.041"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102832"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00415-06"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.032"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00134-12"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1201-1306"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08157"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.5.1725"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.4049\/jimmunol.153.3.1246","article-title":"Administration of anti-IFN-gamma antibody to beta 2-microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype","volume":"153","author":"Sarawar S. R.","year":"1994","unstructured":"S. R. Sarawar, M. Sangster, R. L. Coffman, P. C. Doherty, Administration of anti-IFN-gamma antibody to beta 2-microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype. J. Immunol. 153, 1246\u20131253 (1994).","journal-title":"J. Immunol."},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.1.L69"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.216"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.05.020"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030141"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82378-0"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01785-09"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.09.001"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002202"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01373-13"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701406"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300014"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.016"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.030"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01387"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3308"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.05.019"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3309"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12537"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747303"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003615"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600787"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-071340"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.10.1465"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.06.006"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01122-12"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.10.5447-5455.2003"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.007"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.572749"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.4161\/tisb.24333"},{"key":"e_1_3_4_52_2","first-page":"A4926","article-title":"Interleukin-13 predisposes to more severe influenza infection in mice and human epithelial cells by suppressing interferon responses and activating the microRNA-21\/PI3K signaling pathway","volume":"195","author":"Starkey M. R.","year":"2017","unstructured":"M. R. Starkey , Interleukin-13 predisposes to more severe influenza infection in mice and human epithelial cells by suppressing interferon responses and activating the microRNA-21\/PI3K signaling pathway. Am. J. Respir. Crit. Care Med. 195, A4926 (2017).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1770"},{"key":"e_1_3_4_54_2","first-page":"e150107","article-title":"IL-13 is a driver of COVID-19 severity","volume":"6","author":"Donlan A. N.","year":"2021","unstructured":"A. N. Donlan , IL-13 is a driver of COVID-19 severity. JCI Insight 6, e150107 (2021).","journal-title":"JCI Insight"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12248"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141142"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021207"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011112"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.07.086"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127649"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2020.108859"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813485099"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.154316"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.124719"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-006-0147-9"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2118535119","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2118535119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T20:15:16Z","timestamp":1674764116000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2118535119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":65,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,2,22]]}},"alternative-id":["10.1073\/pnas.2118535119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2118535119","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,15]]},"assertion":[{"value":"2021-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2118535119"}}