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Our findings underlie the importance of mRNA context for the action of protein synthesis inhibitors and might help to guide the development of better antibiotics.<\/jats:p>","DOI":"10.1073\/pnas.2118553119","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T17:01:34Z","timestamp":1642784494000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":23,"title":["The context of the ribosome binding site in mRNAs defines specificity of action of kasugamycin, an inhibitor of translation initiation"],"prefix":"10.1073","volume":"119","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of California, San Francisco, CA 94158"},{"name":"Department of Cell and Tissue Biology, University of California, San Francisco, CA 94158"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3403-7587","authenticated-orcid":false,"given":"Nikolay A.","family":"Aleksashin","sequence":"additional","affiliation":[{"name":"Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Klepacki","sequence":"additional","affiliation":[{"name":"Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb","family":"Anderson","sequence":"additional","affiliation":[{"name":"Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607"},{"name":"Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2256-693X","authenticated-orcid":false,"given":"Nora","family":"V\u00e1zquez-Laslop","sequence":"additional","affiliation":[{"name":"Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607"},{"name":"Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of California, San Francisco, CA 94158"},{"name":"Department of Cell and Tissue Biology, University of California, San Francisco, CA 94158"},{"name":"California Institute of Quantitative Biology, University of California, San Francisco, CA 94158"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3301-827X","authenticated-orcid":false,"given":"Alexander S.","family":"Mankin","sequence":"additional","affiliation":[{"name":"Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1139"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55002"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.248476"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409230903307311"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2010-3"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a032664"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/254034a0"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1983.tb01503.x"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8416-4"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.074"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1249-5"},{"key":"e_1_3_4_12_2","first-page":"753","article-title":"Kasugamycin, a new antibiotic","volume":"5","author":"Umezawa H.","year":"1965","unstructured":"H. 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