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U.S.A."],"published-print":{"date-parts":[[2022,3,15]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Juvenile hormone (JH), a sesquiterpenoid, regulates many aspects of insect development, including maintenance of the larval stage by preventing metamorphosis. In contrast, ecdysteroids promote metamorphosis by inducing the\n                    <jats:italic>E93<\/jats:italic>\n                    transcription factor, which triggers apoptosis of larval cells and remodeling of the larval midgut. We discovered that JH suppresses precocious larval midgut-remodeling by inducing an epigenetic modifier, histone deacetylase 3 (\n                    <jats:italic>HDAC3<\/jats:italic>\n                    ). JH-induced\n                    <jats:italic>HDAC3<\/jats:italic>\n                    deacetylates the histone H4 localized at the promoters of proapoptotic genes, resulting in the suppression of these genes. This eventually prevents programmed cell death of midgut cells and midgut-remodeling during larval stages. These studies identified a previously unknown mechanism of JH action in blocking premature remodeling of the midgut during larval feeding stages.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2118871119","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T15:22:51Z","timestamp":1646752971000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":30,"title":["Juvenile hormone-induced histone deacetylase 3 suppresses apoptosis to maintain larval midgut in the yellow fever mosquito"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-0934","authenticated-orcid":false,"given":"Sharath Chandra","family":"Gaddelapati","sequence":"first","affiliation":[{"name":"Department of Entomology, University of Kentucky, Lexington, KY 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