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Using biochemical, morphological, behavioral, and transcriptional studies, we examined the importance of this interaction for brain function and found that the TCF20 complex plays a direct role in MeCP2-dependent gene regulation and modifies\n                    <jats:italic>MECP2<\/jats:italic>\n                    -induced synaptic and behavioral deficits. Our data uncovered a previously unknown molecular aspect of MeCP2 function and revealed a converging molecular mechanism, whereby mutations of genes encoding several subunits in the same complex contribute to shared neurological symptoms.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2119078119","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T17:40:55Z","timestamp":1643046055000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":39,"title":["Disruption of MeCP2\u2013TCF20 complex underlies distinct neurodevelopmental disorders"],"prefix":"10.1073","volume":"119","author":[{"given":"Jian","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030"},{"name":"Jan and Dan Duncan Neurological Research Institute, Texas Children\u2019s Hospital, Houston, TX 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