{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:15:29Z","timestamp":1781104529920,"version":"3.54.1"},"reference-count":59,"publisher":"National Academy of Sciences","issue":"22","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072661"],"award-info":[{"award-number":["82072661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,5,31]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>This study uncovered the role of ZNF280C, a known DNA damage response protein, as a tumorigenic transcription regulator that contributes to colorectal tumorigenesis and metastasis through maintaining an epigenetic repression program at key cancer gene loci. These findings identified a contributor with potential prognostic value to colorectal pathogenesis and provide mechanistic insight to the essential function of transcription factor in fine-tuning the activity of chromatin regulators for proper transcription control.<\/jats:p>","DOI":"10.1073\/pnas.2120633119","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T15:00:51Z","timestamp":1653318051000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":20,"title":["Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci"],"prefix":"10.1073","volume":"119","author":[{"given":"Ying","family":"Ying","sequence":"first","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"},{"name":"Marshall Laboratory of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"},{"name":"College of Pharmacy, Shenzhen Technology University, Shenzhen, 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongheng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canjie","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0292-5889","authenticated-orcid":false,"given":"Lili","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 00000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 00000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2461-4253","authenticated-orcid":false,"given":"Xing-sheng","family":"Shu","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China"},{"name":"Marshall Laboratory of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61649-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804588"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0230-y"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.013"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0196-7"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01587-3"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.029"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0411-1"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2017.71"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-083115-022339"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3335"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03828-2"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2019.04.001"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.6.2055-2064.2006"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207067"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.10.023"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0532"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2675"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02907"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.33594\/000000104"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0225-0"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.315978.118"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw332"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2296722"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00341-1"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.009"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.082800.108"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku937"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.34"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.509"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018279108"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.142"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55529"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.007"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.166462"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb9149"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz005"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00145-13"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2017.01.007"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504232112"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2019.01.002"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03309-9"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078766"},{"key":"e_1_3_4_45_2","first-page":"5819","article-title":"ZNF280B promotes the growth of gastric cancer in\u00a0vitro and in\u00a0vivo","volume":"15","author":"Zhai J.","year":"2018","unstructured":"J. Zhai , ZNF280B promotes the growth of gastric cancer in\u00a0vitro and in\u00a0vivo. Oncol. Lett. 15, 5819\u20135824 (2018).","journal-title":"Oncol. Lett."},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2019.102686"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1601898"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1704076114"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-1013-1"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-8-r83"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1906"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00821-2"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47081"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.09.006"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4986"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11252"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001453"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-07-0267"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2120633119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T15:02:03Z","timestamp":1653318123000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2120633119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,23]]},"references-count":59,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2022,5,31]]}},"alternative-id":["10.1073\/pnas.2120633119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2120633119","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,23]]},"assertion":[{"value":"2021-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2120633119"}}