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Inhibition of histone deacetylases partially rescues transcriptional alterations upon FOXG1 reduction. This integrated multiomics view of changes upon FOXG1 reduction reveals an unprecedented multimodality of FOXG1 functions converging on neuronal maturation. It fuels therapeutic options based on epigenetic drugs to alleviate, at least in part, neuronal dysfunction.<\/jats:p>","DOI":"10.1073\/pnas.2122467120","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T13:50:10Z","timestamp":1672840210000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":18,"title":["Multimodal epigenetic changes and altered NEUROD1 chromatin binding in the mouse hippocampus underlie FOXG1 syndrome"],"prefix":"10.1073","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0842-6201","authenticated-orcid":false,"given":"Ipek","family":"Akol","sequence":"first","affiliation":[{"name":"Department Molecular Embryology, Institute for Anatomy and Cell Biology, Medical Faculty, University of Freiburg, 79104 Freiburg, Germany"},{"name":"Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-7945","authenticated-orcid":false,"given":"Annalisa","family":"Izzo","sequence":"additional","affiliation":[{"name":"Department Molecular Embryology, Institute for Anatomy and Cell Biology, Medical Faculty, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-1582","authenticated-orcid":false,"given":"Fabian","family":"Gather","sequence":"additional","affiliation":[{"name":"Department Molecular Embryology, Institute for Anatomy and Cell Biology, Medical Faculty, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Strack","sequence":"additional","affiliation":[{"name":"Department Molecular Embryology, Institute for Anatomy and Cell Biology, Medical Faculty, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Heidrich","sequence":"additional","affiliation":[{"name":"Department Molecular Embryology, Institute for Anatomy and Cell Biology, Medical Faculty, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-4833","authenticated-orcid":false,"given":"Darren","family":"\u00d3 hAil\u00edn","sequence":"additional","affiliation":[{"name":"Department Molecular Embryology, Institute for Anatomy and Cell Biology, Medical Faculty, University of Freiburg, 79104 Freiburg, Germany"},{"name":"AUC School of Medicine, University of Central Lancashire, Preston, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8624-8119","authenticated-orcid":false,"given":"Alejandro","family":"Villarreal","sequence":"additional","affiliation":[{"name":"AUC School of Medicine, University of Central Lancashire, Preston, UK"},{"name":"Laboratorio de Neuropatolog\u00eda Molecular, Instituto de Biolog\u00eda Celular y Neurociencia \u201cProf. E. 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