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These polymers can be also mixed with lipids to form the so-called hybrid membranes, which provide further biocompatibility, while new properties emerge. However, the fusion of these hybrids is to date barely explored. Herein, we determined that hybrid vesicles made of poly(dimethylsiloxane)-graft-poly(ethylene oxide) and oppositely charged lipids undergo rapid fusion, surpassing the efficiency in natural membranes. 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