{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:09:21Z","timestamp":1791425361411,"version":"4.3.3"},"reference-count":46,"publisher":"National Academy of Sciences","issue":"22","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,10,29]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>TCL1<\/jats:italic>\n                    protooncogene is overexpressed in many mature B cell lymphomas, especially from AIDS patients. To determine whether aberrant expression promotes B cell transformation, we generated a murine model in which a\n                    <jats:italic>TCL1<\/jats:italic>\n                    transgene was overexpressed at similar levels in both B and T cells. Strikingly, transgenic mice developed Burkitt-like lymphoma (BLL) and diffuse large B cell lymphoma (DLBCL) with attendant Bcl-6 expression and mutated J\n                    <jats:sub>H<\/jats:sub>\n                    gene segments at a very high penetrance beginning at 4 months of age. In contrast, only one mouse developed a T cell malignancy at 15 months, consistent with a longer latency for transformation of T cells by\n                    <jats:italic>TCL1<\/jats:italic>\n                    . Activation of premalignant splenic B cells by means of B cell antigen receptor (BCR) engagement resulted in significantly increased proliferation and augmented AKT-dependent signaling, including increased S6 ribosomal protein phosphorylation. Transgenic spleen cells also survived longer than wild-type spleen cells in long-term culture. Together these data demonstrate that\n                    <jats:italic>TCL1<\/jats:italic>\n                    is a powerful oncogene that, when overexpressed in both B and T cells, predominantly yields mature B cell lymphomas.\n                  <\/jats:p>","DOI":"10.1073\/pnas.212410199","type":"journal-article","created":{"date-parts":[[2002,10,29]],"date-time":"2002-10-29T12:24:11Z","timestamp":1035894251000},"page":"14392-14397","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":97,"title":["Dysregulated\n                    <i>TCL1<\/i>\n                    promotes multiple classes of mature B cell lymphoma"],"prefix":"10.1073","volume":"99","author":[{"given":"Katrina K.","family":"Hoyer","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095; Laboratory of Immunopathology, National Institutes of Health, Bethesda, MD 20892; Developmental Immunology, La Jolla Institute of Allergy and Immunology, San Diego, CA 92121; and Pediatrics and Immunology, University of Washington School of Medicine, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"French","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095; Laboratory of Immunopathology, National Institutes of Health, Bethesda, MD 20892; Developmental Immunology, La Jolla Institute of Allergy and Immunology, San Diego, CA 92121; and Pediatrics and Immunology, University of Washington School of Medicine, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin E.","family":"Turner","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095; Laboratory of Immunopathology, National Institutes of Health, Bethesda, MD 20892; Developmental Immunology, La Jolla Institute of Allergy and Immunology, San Diego, CA 92121; and Pediatrics and Immunology, University of Washington School of Medicine, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai T. N.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095; Laboratory of Immunopathology, National Institutes of Health, Bethesda, MD 20892; Developmental Immunology, La Jolla Institute of Allergy and Immunology, San Diego, CA 92121; and Pediatrics and Immunology, University of Washington School of Medicine, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Renard","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095; Laboratory of Immunopathology, National Institutes of Health, Bethesda, MD 20892; 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Laboratory of Immunopathology, National Institutes of Health, Bethesda, MD 20892; Developmental Immunology, La Jolla Institute of Allergy and Immunology, San Diego, CA 92121; and Pediatrics and Immunology, University of Washington School of Medicine, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Feng","family":"Qi","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095; Laboratory of Immunopathology, National Institutes of Health, Bethesda, MD 20892; Developmental Immunology, La Jolla Institute of Allergy and Immunology, San Diego, CA 92121; and Pediatrics and Immunology, University of Washington School of Medicine, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas T.","family":"Su","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095; 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