{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:52:50Z","timestamp":1789725170621,"version":"4.0.1"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"25","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,12,9]]},"abstract":"<jats:p>\n                    The cingulate gyri in 37 subjects with and without early dementia of the Alzheimer type (DAT) were studied by using MRI at 1.0 mm\n                    <jats:sup>3<\/jats:sup>\n                    isotropic resolution. Groups were segregated into young controls (\n                    <jats:italic>n<\/jats:italic>\n                    = 10), age-matched normal controls (\n                    <jats:italic>n<\/jats:italic>\n                    = 10), very mild DAT (\n                    <jats:italic>n<\/jats:italic>\n                    = 8), and mild DAT (\n                    <jats:italic>n<\/jats:italic>\n                    = 9). By using automated Bayesian segmentation of the cortex and gray matter\/white matter (GM\/WM) isosurface generation, tissue compartments were labeled into gray, white, and cerebrospinal fluid as a function of distance from the GM\/WM isosurface. Cortical mantle distance maps are generated profiling the GM volume and cortical mantle distribution as a function of distance from the cortical surface. Probabilistic tests based on generalizations of Wilcoxon\u2013Mann\u2013Whitney tests were applied to quantify cortical mantle distribution changes with normal and abnormal aging. We find no significant change between young controls and healthy aging as measured by the GM volume and cortical mantle distribution as a function of distance in both anterior and posterior regions of the cingulate. Significant progression of GM loss is seen in the very mild DAT and mild DAT groups in all areas of the cingulate. Posterior regions show both GM volume loss as well as significant cortical mantle distribution decrease with the onset of mild DAT. The \u201cshape of the cortical mantle\u201d as measured by the cortical mantle distance profiles manifests a pronounced increase in variability with mild DAT.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2136624100","type":"journal-article","created":{"date-parts":[[2003,12,9]],"date-time":"2003-12-09T13:17:48Z","timestamp":1070975868000},"page":"15172-15177","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":47,"title":["Labeled cortical mantle distance maps of the cingulate quantify differences between dementia of the Alzheimer type and healthy aging"],"prefix":"10.1073","volume":"100","author":[{"given":"M. I.","family":"Miller","sequence":"first","affiliation":[{"name":"Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218; and Departments of Psychiatry, Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hosakere","sequence":"additional","affiliation":[{"name":"Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218; and Departments of Psychiatry, Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Barker","sequence":"additional","affiliation":[{"name":"Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218; and Departments of Psychiatry, Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Priebe","sequence":"additional","affiliation":[{"name":"Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218; and Departments of Psychiatry, Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218; and Departments of Psychiatry, Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. T.","family":"Ratnanather","sequence":"additional","affiliation":[{"name":"Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218; and Departments of Psychiatry, Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218; and Departments of Psychiatry, Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gado","sequence":"additional","affiliation":[{"name":"Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218; and Departments of Psychiatry, Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218; and Departments of Psychiatry, Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Csernansky","sequence":"additional","affiliation":[{"name":"Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218; and Departments of Psychiatry, Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,12]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.18.2335"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8560"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.103"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1636"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.4.441"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.10.1476"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0848"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0786"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1008"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0428"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0666"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0906"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.650881"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.3.788"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1999)8:4<272::AID-HBM10>3.0.CO;2-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"Hurdal M. K. Bowers P. L. Stephenson K. Sumners D. L. Rehm K. Schaper K. & Rottenberg D. A. (1999) in In: Lecture Notes in Computer Science eds. Taylor C. & Colchester A. (Springer Berlin) pp. 279-286.","DOI":"10.1007\/10704282_31"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(01)00045-1"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.3.326"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.3.397"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1098(1997)8:6<529::AID-IMA5>3.0.CO;2-C"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-6111(89)90285-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1109\/34.730559"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.2307\/3001968"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177730491"},{"key":"e_1_3_2_28_2","unstructured":"Lehmann E. L. (1998) Nonparametrics (Prentice-Hall Englewood Cliffs NJ)."},{"key":"e_1_3_2_29_2","unstructured":"Bradley J. V. (1968) Distribution-Free Statistical Tests. (Prentice-Hall Englewood Cliffs NJ)."},{"key":"e_1_3_2_30_2","unstructured":"Barker A. R. (2003) Masters thesis (The Johns Hopkins University Baltimore MD)."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.5.695"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00994.2003"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00238-6"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.7.637"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.147.6.734"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2136624100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T21:41:03Z","timestamp":1650922863000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2136624100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":35,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2003,12,9]]}},"alternative-id":["10.1073\/pnas.2136624100"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2136624100","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]},"assertion":[{"value":"2003-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}