{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:07:11Z","timestamp":1791558431045,"version":"4.3.4"},"reference-count":74,"publisher":"National Academy of Sciences","issue":"18","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHA 2182\/1-1"],"award-info":[{"award-number":["SCHA 2182\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["NS021328"],"award-info":[{"award-number":["NS021328"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["MH108592"],"award-info":[{"award-number":["MH108592"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["OD010944"],"award-info":[{"award-number":["OD010944"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-16-1-0401"],"award-info":[{"award-number":["W81XWH-16-1-0401"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-21-1-0128"],"award-info":[{"award-number":["W81XWH-21-1-0128"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Primary mitochondrial diseases (PMDs) are the most prevalent inborn metabolic disorders, affecting an estimated 1 in 4,200 individuals. Endurance exercise is generally known to improve mitochondrial function, but its indication in the heterogeneous group of PMDs is unclear. We determined the relationship between mitochondrial mutations, endurance exercise response, and the underlying molecular pathways in mice with distinct mitochondrial mutations. This revealed that mitochondria are crucial regulators of exercise capacity and exercise response. Endurance exercise proved to be mostly beneficial across the different mitochondrial mutant mice with the exception of a worsened dilated cardiomyopathy in ANT1-deficient mice. Thus, therapeutic exercises, especially in patients with PMDs, should take into account the physical and mitochondrial genetic status of the patient.<\/jats:p>","DOI":"10.1073\/pnas.2200549119","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T14:31:31Z","timestamp":1651156291000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":23,"title":["Mitochondrial mutations alter endurance exercise response and determinants in mice"],"prefix":"10.1073","volume":"119","author":[{"given":"Patrick M.","family":"Schaefer","sequence":"first","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arrienne","family":"Butic","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Tan","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-8278","authenticated-orcid":false,"given":"Douglas C.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104"},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61398"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18902"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm114"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217113109"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2021429118"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.12.018"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1147786"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300690110"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi341"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100504"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0797-226"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1700997114"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2008.03.015"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02229"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw4597"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1400-3"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1667-4"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088434"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.067"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0976-8"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/917085"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl149"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073814538512"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10540-007-9042-3"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.02.006"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00054.2012"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-017-0576-y"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3081"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31818313a2"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2010.01289.x"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201438"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12012"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2011.08.002"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2013.102"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1285866"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037887"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0197-3"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00973.2010"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.1.346"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.5604\/20831862.1120932"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2010.055400"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/AC.66.4.2126586"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2007.042945"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200104000-00014"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199102000-00006"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.52.247"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.004"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00400-z"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12548"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2006.00549.x"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-3-19"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-021-00579-4"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-4192-6"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-018-4488-x"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019581108"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00790"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.070037"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP270250"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.018"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001546"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2011-090520"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.04.297"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-020-10021-8"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.06.018"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.938282"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr397"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht188"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.025"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2016.06.002"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23343"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000382"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7831-1_8"},{"key":"e_1_3_4_73_2","first-page":"1","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou Y.","year":"2019","unstructured":"Y. Zhou , Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat. Commun. 10, 1\u201310 (2019).","journal-title":"Nat. Commun."},{"key":"e_1_3_4_74_2","doi-asserted-by":"crossref","unstructured":"P. M. Schaefer . Mitochondrial mutations alter endurance exercise response and determinants in mice. Gene Expression Omnibus (GEO). https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE198229. Deposited 9 March 2022.","DOI":"10.1073\/pnas.2200549119"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2200549119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T17:57:52Z","timestamp":1675447072000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2200549119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,28]]},"references-count":74,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2022,5,3]]}},"alternative-id":["10.1073\/pnas.2200549119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2200549119","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,28]]},"assertion":[{"value":"2022-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2200549119"}}