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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:p>\n                    Aging is the price to pay for acquiring and processing energy through cellular activity and life history productivity. Climate warming can exacerbate the inherent pace of aging, as illustrated by a faster erosion of protective telomere DNA sequences. This biomarker integrates individual pace of life and parental effects through the germline, but whether intra- and intergenerational telomere dynamics underlies population trends remains an open question. Here, we investigated the covariation between life history, telomere length (TL), and extinction risk among three age classes in a cold-adapted ectotherm (\n                    <jats:italic>Zootoca vivipara<\/jats:italic>\n                    ) facing warming-induced extirpations in its distribution limits. TL followed the same threshold relationships with population extinction risk at birth, maturity, and adulthood, suggesting intergenerational accumulation of accelerated aging rate in declining populations. In dwindling populations, most neonates inherited already short telomeres, suggesting they were born physiologically old and unlikely to reach recruitment. At adulthood, TL further explained females\u2019 reproductive performance, switching from an index of individual quality in stable populations to a biomarker of reproductive costs in those close to extirpation. We compiled these results to propose the aging loop hypothesis and conceptualize how climate-driven telomere shortening in ectotherms may accumulate across generations and generate tipping points before local extirpation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2201371119","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T15:16:07Z","timestamp":1659971767000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":53,"title":["Lizards from warm and declining populations are born with extremely short telomeres"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-464X","authenticated-orcid":false,"given":"Andr\u00e9az","family":"Dupou\u00e9","sequence":"first","affiliation":[{"name":"Laboratoire des sciences de l'environnement marin, Centre National de la Recherche Scientifique, Universit\u00e9 Bretagne Occidentale, Institut de recherche pour le d\u00e9veloppement, Institut Fran\u00e7ais de Recherche pour l'Exploitation de la Mer, UMR 6539, Plouzan\u00e9, 29280, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Blaimont","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064"},{"name":"Department of Biology, Rider University, Lawrenceville, NJ 08648"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Angelier","sequence":"additional","affiliation":[{"name":"Centre d\u2019Etudes Biologiques de Chiz\u00e9, Universit\u00e9 de La Rochelle, CNRS, UMR 7372, Beauvoir sur Niort, 79360, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Ribout","sequence":"additional","affiliation":[{"name":"Centre d\u2019Etudes Biologiques de Chiz\u00e9, Universit\u00e9 de La Rochelle, CNRS, UMR 7372, Beauvoir sur Niort, 79360, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rozen-Rechels","sequence":"additional","affiliation":[{"name":"Institut d'\u00e9cologie et des sciences de l'environnement de Paris, CNRS, UMR 7618, Sorbonne Universit\u00e9, Paris, 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2135-8194","authenticated-orcid":false,"given":"Murielle","family":"Richard","sequence":"additional","affiliation":[{"name":"Station d\u2019Ecologie Th\u00e9orique et Exp\u00e9rimentale de Moulis, CNRS, UMR 5321, Saint Girons, 09200, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5768-179X","authenticated-orcid":false,"given":"Donald","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ohio University, Athens, OH 45701"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-6104","authenticated-orcid":false,"given":"Pierre","family":"de Villemereuil","sequence":"additional","affiliation":[{"name":"Institut de Syst\u00e9matique, \u00c9volution, Biodiversit\u00e9, CNRS, Mus\u00e9um national d\u2019Histoire naturelle, Sorbonne Universit\u00e9, Ecole Pratique des Hautes Etudes and Universit\u00e9 des Antilles, UMR 7205, Paris, 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Rutschmann","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Auckland, Auckland, 1142, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-6613","authenticated-orcid":false,"given":"Arnaud","family":"Badiane","sequence":"additional","affiliation":[{"name":"Institut d'\u00e9cologie et des sciences de l'environnement de Paris, CNRS, UMR 7618, Sorbonne Universit\u00e9, Paris, 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-8659","authenticated-orcid":false,"given":"Fabien","family":"Aubret","sequence":"additional","affiliation":[{"name":"Station d\u2019Ecologie Th\u00e9orique et Exp\u00e9rimentale de Moulis, CNRS, UMR 5321, Saint Girons, 09200, France"},{"name":"School of Agricultural, Environmental and Veterinary Sciences, Faculty of Science and Health, Charles Sturt University, Port Macquarie NSW 2444, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lourdais","sequence":"additional","affiliation":[{"name":"Centre d\u2019Etudes Biologiques de Chiz\u00e9, Universit\u00e9 de La Rochelle, CNRS, UMR 7372, Beauvoir sur Niort, 79360, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Meylan","sequence":"additional","affiliation":[{"name":"Institut d'\u00e9cologie et 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Bleu, M. Massot, C. Haussy, S. Meylan, Experimental litter size reduction reveals costs of gestation and delayed effects on offspring in a viviparous lizard. Proc. Biol. Sci. 279, 489\u2013498 (2012).","journal-title":"Proc. Biol. Sci."},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219805"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0435"},{"key":"e_1_3_4_57_2","first-page":"1","article-title":"Telomeres in a spatial context: A tool for understanding ageing pattern variation in wild populations","volume":"44","author":"Burraco P.","year":"2021","unstructured":"P. Burraco, P. M. Lucas, P. Salm\u00f3n, Telomeres in a spatial context: A tool for understanding ageing pattern variation in wild populations. 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Mackay, Introduction to Quantitative Genetics (Longmans Green, Harlow, ed. 4, 1996).","edition":"4"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2201371119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T15:18:36Z","timestamp":1659971916000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2201371119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":72,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2022,8,16]]}},"alternative-id":["10.1073\/pnas.2201371119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2201371119","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,8]]},"assertion":[{"value":"2022-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2201371119"}}