{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:45:52Z","timestamp":1790063152925,"version":"4.0.1"},"reference-count":59,"publisher":"National Academy of Sciences","issue":"21","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,5,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>We report the discovery of fundamental roles for the noncanonical inflammasome molecule Caspase-4\/11 in promoting pathological inflammatory and prothrombotic pathways in severe acute respiratory syndrome coronavirus 2 (SARS\u2013CoV-2) infections. Our work demonstrates that Caspase-11 has a broader role in immune responses beyond its previously appreciated effects in bacterial infections. Further, we show that Caspase-11\u2013deficient mice infected with SARS\u2013CoV-2 fare significantly better in terms of overall illness, lung inflammation, and thrombosis than wild-type (WT) mice, thus implicating Caspase-11 as a new therapeutic target for preventing or treating COVID-19.<\/jats:p>","DOI":"10.1073\/pnas.2202012119","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T14:18:38Z","timestamp":1652969918000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":59,"title":["Caspase-4\/11 exacerbates disease severity in SARS\u2013CoV-2 infection by promoting inflammation and immunothrombosis"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4056-7429","authenticated-orcid":false,"given":"Mostafa M.","family":"Eltobgy","sequence":"first","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Neuroscience graduate program, The Ohio State University, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Zani","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam D.","family":"Kenney","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shady","family":"Estfanous","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"},{"name":"Faculty of Pharmacy, Helwan University, Cairo,11731 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4196-8280","authenticated-orcid":false,"given":"Eunsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Badr","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cierra","family":"Carafice","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7740-4685","authenticated-orcid":false,"given":"Kylene","family":"Daily","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Whitham","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Pietrzak","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7005-5304","authenticated-orcid":false,"given":"Jeffrey","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian C.","family":"Eddy","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9420-1337","authenticated-orcid":false,"given":"Parker","family":"Denz","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4438-980X","authenticated-orcid":false,"given":"Mijia","family":"Lu","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5177-9566","authenticated-orcid":false,"given":"Mahesh","family":"KC","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"},{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH 43205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Peeples","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"},{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH 43205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Li","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"},{"name":"Department of Pathology, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-6701","authenticated-orcid":false,"given":"Jianwen","family":"Que","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases and Center for Human Development, Department of Medicine, Columbia University, New York, NY 10027"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4699-515X","authenticated-orcid":false,"given":"Richard","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-1512","authenticated-orcid":false,"given":"Oscar","family":"Rosas Mejia","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0659-559X","authenticated-orcid":false,"given":"Rachael E.","family":"Rayner","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2531-4797","authenticated-orcid":false,"given":"Luanne","family":"Hall-Stoodley","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Seveau","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail A.","family":"Gavrilin","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6440-7414","authenticated-orcid":false,"given":"Jeronay","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"Kohlmeier","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2686-8380","authenticated-orcid":false,"given":"Mehul S.","family":"Suthar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322"},{"name":"Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322"},{"name":"Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2513-7156","authenticated-orcid":false,"given":"Eugene","family":"Oltz","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Chronic Brain Injury Discovery Theme, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5583-9194","authenticated-orcid":false,"given":"Frank H.","family":"Robledo-Avila","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH 43205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-9440","authenticated-orcid":false,"given":"Santiago","family":"Partida-Sanchez","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH 43205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Hemann","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2679-0579","authenticated-orcid":false,"given":"Eman","family":"Abdelrazik","sequence":"additional","affiliation":[{"name":"Center for Informatics Science, Nile University, Giza, 12525, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Forero","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0317-8731","authenticated-orcid":false,"given":"Shahid M.","family":"Nimjee","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-9088","authenticated-orcid":false,"given":"Prosper N.","family":"Boyaka","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Cormet-Boyaka","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob S.","family":"Yount","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-7536","authenticated-orcid":false,"given":"Amal O.","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH 43210"},{"name":"Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2020-138386"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108804"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00798-x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2020-0359PS"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2020-0346"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-016794"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201707"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2020-138791"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.001"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1491494"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0228-2"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","unstructured":"C. Junqueira SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes pyroptosis and cytokine release. medRxiv [Preprint] (2021). https:\/\/doi.org\/10.1101\/2021.03.06.21252796. Accessed 8 March 2021.","DOI":"10.1101\/2021.03.06.21252796"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007105"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94495"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948109"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aar6676"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abh2169"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01895"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.050"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02749-21"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2312-y"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-0762"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02519"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc2061"},{"key":"e_1_3_4_26_2","first-page":"291","article-title":"Quantification of histochemical staining by color deconvolution","volume":"23","author":"Ruifrok A. C.","year":"2001","unstructured":"A. C. Ruifrok, D. A. Johnston, Quantification of histochemical staining by color deconvolution. Anal. Quant. Cytol. Histol. 23, 291\u2013299 (2001).","journal-title":"Anal. Quant. Cytol. Histol."},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007008"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06062-x"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2021.03.023"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201012"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25882"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009233"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.015"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10558"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12787"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf3036"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.06.016"},{"key":"e_1_3_4_38_2","first-page":"5304","article-title":"The role of oxidized phospholipids in COVID-19-associated hypercoagulopathy","volume":"25","author":"Akp\u0131nar S.","year":"2021","unstructured":"S. Akp\u0131nar , The role of oxidized phospholipids in COVID-19-associated hypercoagulopathy. Eur. Rev. Med. Pharmacol. Sci. 25, 5304\u20135309 (2021).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02519"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.05.003"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108249"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1803139"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.701278"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101069"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","unstructured":"T. H. Lee SARS-CoV-2 infection reduces Kr\u00fcppel-like factor 2 in human lung autopsy. bioRxiv [Preprint] (2021). https:\/\/doi.org\/10.1101\/2021.01.15.426691. Accessed 18 January 2021.","DOI":"10.1101\/2021.01.15.426691"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015432"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30937-5"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21085-8"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02012-06"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150606"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.705581"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11030138"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30533-3"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.085"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-019-3251-1"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2202012119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T14:19:48Z","timestamp":1652969988000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2202012119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,19]]},"references-count":59,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2022,5,24]]}},"alternative-id":["10.1073\/pnas.2202012119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2202012119","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.24.461743","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,19]]},"assertion":[{"value":"2022-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2202012119"}}